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rs1050450

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 common in clinvar
Make rs1050450(C;T)
Make rs1050450(T;T)
ReferenceGRCh38 38.1/141
Chromosome3
Position49357401
GeneGPX1, LOC100289130
is asnp
is mentioned by
dbSNPrs1050450
ebirs1050450
HLIrs1050450
Exacrs1050450
Varsomers1050450
Maprs1050450
PheGenIrs1050450
hapmaprs1050450
1000 genomesrs1050450
hgdprs1050450
ensemblrs1050450
gopubmedrs1050450
geneviewrs1050450
scholarrs1050450
googlers1050450
pharmgkbrs1050450
gwascentralrs1050450
openSNPrs1050450
23andMers1050450
23andMe allrs1050450
SNP Nexus

SNPshotrs1050450
SNPdbers1050450
MSV3drs1050450
GWAS Ctlgrs1050450
GMAF0.2493
Max Magnitude0

[PMID 19505917OA-icon.png] Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors


[PMID 20178852] Association Study between Polymorphisms in Selenoprotein Genes and Susceptibility to Kashin-Beck Disease


[PMID 21062213] Manganese superoxide dismutase dimorphism relationship with severity and prognosis in cardiogenic shock due to dilated cardiomyopathy

[PMID 21185702] Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus


[PMID 21795425OA-icon.png] Genetic Variation in Myeloperoxidase Modifies the Association of Serum {alpha}-Tocopherol with Aggressive Prostate Cancer among Current Smokers

OMIM138320
Desc
Variant0001
Relatedalso


ClinVar
Risk rs1050450(T;T)
Alt rs1050450(T;T)
Reference rs1050450(C;C)
Significance Non-pathogenic
Disease GLUTATHIONE PEROXIDASE POLYMORPHISM
Variation info
Gene GPX1
CLNDBN GLUTATHIONE PEROXIDASE POLYMORPHISM
Reversed 1
HGVS NC_000003.11:g.49394834G>A
CLNSRC OMIM Allelic Variant
CLNACC RCV000017462.2,



[PMID 16797832] GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer.

[PMID 16945136OA-icon.png] Gene x Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study.

[PMID 17825092OA-icon.png] Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography.

[PMID 18298806OA-icon.png] Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years.

[PMID 18340529OA-icon.png] A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk.

[PMID 18682580OA-icon.png] Oxidative response gene polymorphisms and risk of adult brain tumors.

[PMID 19428448OA-icon.png] The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old.

[PMID 19946932] Lack of association of GPX1 and MnSOD genes with symptom severity and response to clozapine treatment in schizophrenia subjects.

[PMID 20003265OA-icon.png] Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast.

[PMID 20444272OA-icon.png] Gene polymorphisms against DNA damage induced by hydrogen peroxide in leukocytes of healthy humans through comet assay: a quasi-experimental study.

[PMID 20852007] Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men.

[PMID 21595856] Genetic polymorphisms in antioxidative enzymes are associated to forced expiratory volume in 1 s (FEV1) in smokers independently of asthma.

[PMID 21842217] GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis.

[PMID 22139612OA-icon.png] Serum selenium and single-nucleotide polymorphisms in genes for selenoproteins: relationship to markers of oxidative stress in men from Auckland, New Zealand.

[PMID 22661588OA-icon.png] Antioxidant enzyme polymorphisms and neuropsychological outcomes in medulloblastoma survivors: a report from the Childhood Cancer Survivor Study.


[PMID 23073788] GPX1 gene Pro200Leu polymorphism, erythrocyte GPX activity, and cancer risk


GET Evidence
GPX1-P199L
aa_change Pro199Leu
aa_change_short P199L
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.28988
summary



[PMID 23906684] Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants


[PMID 23363810] Prostate disease risk factors among a New Zealand cohort


[PMID 24610081] Associations Between SNPs Within Antioxidant Genes and the Risk of Prostate Cancer in the Siberian Region of Russia


[PMID 22877234OA-icon.png] Polymorphisms in genes involved in oxidative stress response in patients with sudden sensorineural hearing loss and Meniere's disease in a Japanese population.


[PMID 23175176OA-icon.png] Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype.


[PMID 24058403OA-icon.png] Association study of polymorphisms in selenoprotein genes and Kashin-Beck disease and serum selenium/iodine concentration in a Tibetan population


[PMID 25009565OA-icon.png] Association of glutathione peroxidase-1 (GPx-1) rs1050450 Pro198Leu and Pro197Leu polymorphisms with cardiovascular risk: a meta-analysis of observational studies


[PMID 25182984] [Association between GPX-1 single nucleotide polymorphisms and susceptibility to noise-induced hearing loss among Chinese Han population]


[PMID 25497738] Effect of 593C>T GPx1 SNP alone and in synergy with 47C>T SOD2 SNP on the outcome of critically ill patients


[PMID 26081749] Antioxidant-related gene polymorphisms associated with the cardio-ankle vascular index in young Russians


[PMID 24517502] Gene variants encoding proteins involved in antioxidant defense system and the clinical expression of Wilson disease


[PMID 26446998] Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1


[PMID 27480094] Association of interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers.


[PMID 27825163] Effects of GSTP1 and GPX1 Polymorphisms on the Risk of Preeclampsia in Chinese Han Women.