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rs10505806

From SNPedia

Stabilizedplus
Geno Mag Summary
(A;A) 2 common/normal; aspirin use reduces colorectal cancer risk a bit
(A;T) 2 aspirin use may increase colorectal cancer risk a bit
(T;T) 2 aspirin use may increase colorectal cancer risk a bit
is asnp
is mentioned by
dbSNPrs10505806
ebirs10505806
HLIrs10505806
Exacrs10505806
Varsomers10505806
Maprs10505806
PheGenIrs10505806
hapmaprs10505806
1000 genomesrs10505806
hgdprs10505806
ensemblrs10505806
gopubmedrs10505806
geneviewrs10505806
scholarrs10505806
googlers10505806
pharmgkbrs10505806
gwascentralrs10505806
openSNPrs10505806
23andMers10505806
23andMe allrs10505806
SNP Nexus

SNPshotrs10505806
SNPdbers10505806
MSV3drs10505806
GWAS Ctlgrs10505806
Max Magnitude2
? (A;A) (A;T) (T;T) 28
rs10505806 is a SNP on chromosome 12.

In a long-term study of ~17,000 individuals and aspirin or NSAID use, the few (5%) with either an (A;T) or (T;T) genotype were almost twice as likely to be diagnosed with colorectal cancer compared with (A;A) individuals among those taking anti-inflammatory drugs ((A;T) and (T;T) odds ratio 1.56 when taking aspirin/NSAID).10.1001/jama.2015.1815

If this data is robust and all other factors are equal, this indicates that most people will lower their colorectal cancer risk by taking aspirin or NSAIDs, since most people have rs10505086(A;A) genotypes. However, the few people who are rs10505806(A;T) or are rs10505806(T;T) should not take aspirin or NSAIDs since doing so may actually raise their colorectal risk.

This same study reached somewhat similar conclusions about two other SNPs, rs2965667 and rs16973225.10.1001/jama.2015.1815