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rs10507391

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) normal
(A;T) 1.24x increased stroke risk for males
(T;T) 1.24x increased stroke risk for males
ReferenceGRCh38 38.1/141
Chromosome13
Position30737959
GeneALOX5AP
is asnp
is mentioned by
dbSNPrs10507391
ebirs10507391
HLIrs10507391
Exacrs10507391
Varsomers10507391
Maprs10507391
PheGenIrs10507391
hapmaprs10507391
1000 genomesrs10507391
hgdprs10507391
ensemblrs10507391
gopubmedrs10507391
geneviewrs10507391
scholarrs10507391
googlers10507391
pharmgkbrs10507391
gwascentralrs10507391
openSNPrs10507391
23andMers10507391
23andMe allrs10507391
SNP Nexus

SNPshotrs10507391
SNPdbers10507391
MSV3drs10507391
GWAS Ctlgrs10507391
GMAF0.489
Max Magnitude
? (A;A) (A;T) (T;T) 28
rs10507391, also known as SG13S114, is an ALOX5AP gene SNP that has been defined as part of a haplotype potentially associated with risk for myocardial infarction or ischemic stroke. Details of this haplotype and several related studies are on the ALOX5AP page.

One study that specifically found association for rs10507391 involved 639 German ischemic stroke patients. The association was statistically significant (only) in males, with an odds ratio of 1.24 (CI: 1.04-1.55, p=0.017).[PMID 15731479]


[PMID 20067482OA-icon.png] The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos


[PMID 21153769] A tagging SNP in ALOX5AP and risk of stroke: a haplotype-based analysis among eastern Chinese Han population


[PMID 22051033] ALOX5AP genetic variants and risk of atherothrombotic stroke in the Taiwanese population

[PMID 17903304OA-icon.png] Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes.

[PMID 19130089OA-icon.png] Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.

[PMID 19665766OA-icon.png] Genetics and pharmacogenetics of the leukotriene pathway.

[PMID 20592751OA-icon.png] Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.

[PMID 20810156OA-icon.png] ALOX5AP and LTA4H polymorphisms modify augmentation of bronchodilator responsiveness by leukotriene modifiers in Latinos.


[PMID 23765972] Interaction between ALOX5AP-SG13S114A/T and COX-2-765G/C increases susceptibility to cerebral infarction in a Chinese population


[PMID 24368493] Interaction between ALOX5AP and CYP3A5 gene variants significantly increases the risk for cerebral infarctions in Chinese


[PMID 26885075] A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population.


[PMID 26944113] Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index.