|(C;G)||2.1||normal for bladder cancer risk; 1.9x increased risk for gallbladder cancer|
|(G;G)||2.2||2x increased bladder cancer risk; 4.5x increased risk for gallbladder cancer|
A study of 250 Japanese patients with bladder cancer found an adjusted odds ratio of 2.05 (CI: 1.36-3.08; p = 0.01) for (G;G) homozygotes compared to the other genotypes. In addition, if evaluated only in non-smokers, the adjusted odds ratio increased to 2.78 (CI: 1.39-5.60; p < 0.01).[PMID 18272472]
A study of 200 Chinese patients with gallbladder cancer concluded that increased risk was associated with both the (C;G) genotype (odds ratio 1.9, (CI: = 1.0-3.7) and the (G;G) genotype (odds ratio 4.5, CI: 1.1-22.4).[PMID 17417784]
A study of 300 lung cancer patients of various ethnicities found that the (G;G) genotype was associated with an odds ratio of 2.1 (CI: 1.2-3.7), regardless of sex or ethnicity.[PMID 11927502] However, a Danish study of 400 lung cancer patients found no association.[PMID 17015267]
[PMID 19266243] Single-Nucleotide Polymorphisms of DNA Repair Genes OGG1 and XRCC1: Association with Gallbladder Cancer in North Indian Population
[PMID 19561388] Common Polymorphisms in the XPD and hOGG1 Genes Are Not Associated with the Risk of Colorectal Cancer in a Polish Population
[PMID 19815090] The Relation between Endothelial Nitric Oxide Synthase Gene Variants and Primary Open-Angle Glaucoma: Interactions with Gender and Postmenopausal Hormone Use
[PMID 20069464] OGG1 Ser326Cys Polymorphism and Susceptibility to Esophageal Cancer in Low and High At-Risk Populations of Northern India
[PMID 20571908] MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: a case control study
[PMID 20606456] The Ser(326)Cys Polymorphism of 8-Oxoguanine Glycosylase 1 (OGG1) Is Associated with Type 2 Diabetes in Mexican Americans
[PMID 21283657] Gallbladder Cancer Predisposition: A Multigenic Approach to DNA-Repair, Apoptotic and Inflammatory Pathway Genes
|Disease Association||Defects in OGG1 are a cause of renal cell carcinoma (RCC1) (MIM:144700).|
[PMID 21622940] Single Nucleotide Polymorphisms in DNA Repair Genes and Association with Breast Cancer Risk in the WEB Study
[PMID 21727658] Protective association exhibited by the single nucleotide polymorphism (SNP) rs1052133 in the gene human 8-oxoguanine DNA glycosylase (hOGG1) with the risk of squamous cell carcinomas of the head & neck (SCCHN) among north Indians
[PMID 21915362] Sequence variants in antioxidant defense and DNA repair genes, dietary antioxidants, and pancreatic cancer risk
[PMID 21914193] The hOGG1 Ser326Cys Polymorphism and Prostate Cancer Risk: A Meta-Analysis of 2584 cases and 3234 controls
[PMID 21129811] Associations between polymorphisms in DNA repair genes and TP53 mutations in non-small cell lung cancer
[PMID 21338322] Parameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitus
[PMID 22540013] The Association between OGG1 Ser326Cys Polymorphism and Lung Cancer Susceptibility: A Meta-Analysis of 27 Studies
[PMID 22659345] Polymorphisms of DNA repair genes in Korean hepatocellular carcinoma patients with chronic hepatitis B: possible implications on survival
[PMID 16465622] Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes.
[PMID 17220334] High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility.
[PMID 17984110] Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China.
[PMID 18191955] Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.
[PMID 18544627] Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk.
[PMID 18547414] Genotyping panel for assessing response to cancer chemotherapy.
[PMID 18569589] Rapid detection of the hOGG1 Ser326Cys polymorphism using LightCycler technology.
[PMID 18823566] Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population.
[PMID 18936436] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
[PMID 18990748] International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.
[PMID 18992148] Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
[PMID 19029194] Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans.
[PMID 19098027] SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms.
[PMID 19124499] Association and interactions between DNA repair gene polymorphisms and adult glioma.
[PMID 19318434] Associations between polymorphisms in DNA repair genes and glioblastoma.
[PMID 19443904] Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma.
[PMID 19536092] Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.
[PMID 19674107] Substrate specificity and excision kinetics of natural polymorphic variants and phosphomimetic mutants of human 8-oxoguanine-DNA glycosylase.
[PMID 19881468] hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type.
[PMID 20564624] Polymorphisms in ERCC2, MSH2, and OGG1 DNA repair genes and gallbladder cancer risk in a population of Northern India.
[PMID 20577654] XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium.
[PMID 21166493] hOGG1 Ser326Cys polymorphism and renal cell carcinoma risk in a Chinese population.
[PMID 21183201] DNA repair gene polymorphisms at XRCC1, XRCC3, XPD, and OGG1 loci in Maharashtrian population of central India.
[PMID 21195504] Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk.
[PMID 21401806] hOGG1 Ser326Cys polymorphism and risk of childhood acute lymphoblastic leukemia in a Chinese population.
[PMID 21561390] Association of APE1 and hOGG1 polymorphisms with colorectal cancer risk in a Turkish population.
[PMID 21695387] Association of OGG1 Ser326Cys polymorphism with colorectal cancer risk: a meta-analysis.
[PMID 21708280] Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis.
[PMID 21741876] Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk.
[PMID 21974800] DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome.
[PMID 22469746] Association between polymorphisms of the DNA base excision repair genes MUTYH and hOGG1 and age-related macular degeneration.
[PMID 22687647] Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population.
[PMID 22720119] Association of base excision repair gene polymorphisms with ESRD risk in a Chinese population
[PMID 23079842] Meta-analysis demonstrates lack of association of the hOGG1 Ser326Cys polymorphism with bladder cancer risk
|qualified_impact||Insufficiently evaluated not reviewed|
[PMID 22850545] Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese
[PMID 24022861] An NEIL1 single nucleotide polymorphism (rs4462560) predicts the risk of radiation-induced toxicities in esophageal cancer patients treated with definitive radiotherapy
[PMID 24499375] Association of Oxidative Stress Related Genes with Idiopathic Recurrent Miscarriage
[PMID 24500421] Association between DNA repair gene polymorphisms and risk of glioma: A systematic review and meta-analysis
[PMID 22466227] Genotoxic effects of occupational exposure to lead and influence of polymorphisms in genes involved in lead toxicokinetics and in DNA repair.
[PMID 24036326] Genotoxic effect of exposure to metal(loid)s. A molecular epidemiology survey of populations living and working in Panasqueira mine area, Portugal
[PMID 23959014] DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia
[PMID 25703835] Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case-control study. The HUNT Study
[PMID 25907663] hOGG1 C1245G gene polymorphism associated with prostate cancer: a meta-analysis
[PMID 26074017] Association between single nucleotide polymorphisms of MUTYH, hOGG1 and NEIL1 genes, and depression
[PMID 26159902] DNA Repair Gene Polymorphisms in Relation to Non-Small Cell Lung Cancer Survival
[PMID 26400813] DNA Base-Excision Repair Genes OGG1 and NTH1 in Brazilian Lung Cancer Patients
[PMID 26585352] Associations between circulating carotenoids, genomic instability and the risk of high-grade prostate cancer
[PMID 26634519] XRCC1 rs25487 polymorphism is associated with lung cancer risk in epidemiologically susceptible Chinese people.
[PMID 27603140] The association analysis of hOGG1 genetic variants and gastric cancer risk in a Chinese population.