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rs10553596

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(TT;TT) 0 common/normal
Make rs10553596(-;-)
Make rs10553596(-;TT)
ReferenceGRCh38.p2 38.2/147
Chromosome10
Position113679882
GeneCASP7
is asnp
is mentioned by
dbSNPrs10553596
ebirs10553596
HLIrs10553596
Exacrs10553596
Varsomers10553596
Maprs10553596
PheGenIrs10553596
hapmaprs10553596
1000 genomesrs10553596
hgdprs10553596
ensemblrs10553596
gopubmedrs10553596
geneviewrs10553596
scholarrs10553596
googlers10553596
pharmgkbrs10553596
gwascentralrs10553596
openSNPrs10553596
23andMers10553596
23andMe allrs10553596
SNP Nexus

SNPshotrs10553596
SNPdbers10553596
MSV3drs10553596
GWAS Ctlgrs10553596
Max Magnitude0
rs10553596 represents a fairly common variant in the CASP7 gene on chromosome 10, consisting of a deletion of two bases (TT). Roughly 25% of any population carry at least one rs10553596(-) alleles, with somewhat higher frequencies in African populations.


An intriguing - though preliminary - report indicates that ApoE4 homozygotes, who are at relatively high risk for late-onset Alzheimer's disease, have their risk reduced (by about half) if they carry at least one rs10553596 minor allele, although it is also possible that the variant delays the age of onset (rather than protects against the disease). The protective effect was not observed for ApoE4 heterozygotes.[PMID 27358062OA-icon.png]