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rs1059703

From SNPedia

Orientationminus
Stabilizedminus
Make rs1059703(C;C)
Make rs1059703(C;T)
Make rs1059703(T;T)
ReferenceGRCh38 38.1/141
ChromosomeX
Position154013378
GeneIRAK1
is asnp
is mentioned by
dbSNPrs1059703
ebirs1059703
HLIrs1059703
Exacrs1059703
Varsomers1059703
Maprs1059703
PheGenIrs1059703
hapmaprs1059703
1000 genomesrs1059703
hgdprs1059703
ensemblrs1059703
gopubmedrs1059703
geneviewrs1059703
scholarrs1059703
googlers1059703
pharmgkbrs1059703
gwascentralrs1059703
openSNPrs1059703
23andMers1059703
23andMe allrs1059703
SNP Nexus

SNPshotrs1059703
SNPdbers1059703
MSV3drs1059703
GWAS Ctlgrs1059703
GMAF0.4305
Max Magnitude
? (C;C) (C;T) (T;T) 28
The C->T (Ser532Leu, rs1059703) polymorphism of the IRAK1 gene was significantly associated with atherothrombotic cerebral infarction in a study of 3,400+ Japanese adults.[PMID 18566305]

[PMID 20500689] The Role of microRNA-146a (miR-146a) and its Target IL-1R-Associated Kinase (IRAK1) in Psoriatic Arthritis Susceptibility

[PMID 20870441] A polymorphism in the 3'-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility [PMID 17382928OA-icon.png] The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study.


[PMID 18987746OA-icon.png] Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination.


[PMID 19288030] Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus.


[PMID 19505919OA-icon.png] Toll-like receptor signaling pathway variants and prostate cancer mortality.


[PMID 20463618OA-icon.png] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

GET Evidence
IRAK1-S532L
aa_change Ser532Leu
aa_change_short S532L
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.778922
summary



[PMID 23233309] An activity-enhancing variant of IRAK1 and an MECP2-IRAK1 haplotype associating with increased susceptibility to rheumatoid arthritis

[PMID 23867959OA-icon.png] Toll-like receptor genetic variants are associated with Gram-negative infections in VLBW infants

[PMID 25458699] Variants in IRAK1-MECP2 region confer susceptibility to autoimmune thyroid diseases