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rs1062613

From SNPedia

Orientationplus
Stabilizedplus
Make rs1062613(C;C)
Make rs1062613(C;T)
Make rs1062613(T;T)
ReferenceGRCh38 38.1/141
Chromosome11
Position113975284
GeneHTR3A
is asnp
is mentioned by
dbSNPrs1062613
ebirs1062613
HLIrs1062613
Exacrs1062613
Varsomers1062613
Maprs1062613
PheGenIrs1062613
hapmaprs1062613
1000 genomesrs1062613
hgdprs1062613
ensemblrs1062613
gopubmedrs1062613
geneviewrs1062613
scholarrs1062613
googlers1062613
pharmgkbrs1062613
gwascentralrs1062613
openSNPrs1062613
23andMers1062613
23andMe allrs1062613
SNP Nexus

SNPshotrs1062613
SNPdbers1062613
MSV3drs1062613
GWAS Ctlgrs1062613
GMAF0.2337
Max Magnitude
? (C;C) (C;T) (T;T) 28
Rs1062613 (C178T, Pro16Ser) is located within the 5' UTR of HTR3A and may effect HTR3A expression.

[PMID 11505217] reporter constructs containing the T allele showed increased HTR3A expression compared to the C allele

[PMID 14557147] CC and CT carriers associated with higher harm avoidance (p = 0.04) scores in 2 sample groups of Swedish women (366 in total), and non-conformity in 1 sample

[PMID 18359159] no significant association between treatment-resistant schizophrenia and Rs1062613, however, maintenance neuroleptic dose was significantly higher for TT carriers (p = 0.041)



[PMID 20168265] Influence of serotonin 3A and 3B receptor genes on clozapine treatment response in schizophrenia


[PMID 21420406OA-icon.png] The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome.


[PMID 22700043] Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia


[PMID 23290502OA-icon.png] Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers