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rs10754339

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;G) 1.3 1.3x increased risk of breast cancer
(G;G) 1.4 1.45x increased risk of breast cancer
ReferenceGRCh38 38.1/141
Chromosome1
Position117147650
GeneVTCN1
is asnp
is mentioned by
dbSNPrs10754339
ebirs10754339
HLIrs10754339
Exacrs10754339
Varsomers10754339
Maprs10754339
PheGenIrs10754339
hapmaprs10754339
1000 genomesrs10754339
hgdprs10754339
ensemblrs10754339
gopubmedrs10754339
geneviewrs10754339
scholarrs10754339
googlers10754339
pharmgkbrs10754339
gwascentralrs10754339
openSNPrs10754339
23andMers10754339
23andMe allrs10754339
SNP Nexus

SNPshotrs10754339
SNPdbers10754339
MSV3drs10754339
GWAS Ctlgrs10754339
GMAF0.2388
Max Magnitude1.4
? (A;A) (A;G) (G;G) 28
rs10754339 is a SNP in the V-set domain containing T cell activation inhibitor 1 VTCN1 gene, which is also known as B7-H4.

A study of 500 Chinese Han women with breast cancer (and an equal number of matched controls) concluded that the rs10754339(A;G) genotype and G allele showed a significantly increased risk of breast cancer (odds ratio 1.455, CI: 1.119-1.892, and 1.325, CI: 1.073-1.637, respectively). Additionally, the rs10754339(G;G) genotype was significantly associated with lymph node metastasis and PR status, and the G allele and the (A;G) genotype were respectively associated with lymph node metastasis and ER status.[PMID 19903360OA-icon.png]


[PMID 19756043OA-icon.png] A simple and efficient algorithm for genome-wide homozygosity analysis in disease.


[PMID 24125968] An investigation of the effects of FGFR2 and B7-H4 polymorphisms in breast cancer


[PMID 25900029] SNP-SNP interactions of immunity related genes involved into CD28/B7 pathway with susceptibility to invasive ductal carcinoma of the breast