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rs10761659

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 1.5x risk of Crohn's disease
(A;G) 1 1.2x risk of Crohn's disease
(G;G) 0 normal
ReferenceGRCh38 38.1/142
Chromosome10
Position62685804
is asnp
is mentioned by
dbSNPrs10761659
ebirs10761659
HLIrs10761659
Exacrs10761659
Varsomers10761659
Maprs10761659
PheGenIrs10761659
hapmaprs10761659
1000 genomesrs10761659
hgdprs10761659
ensemblrs10761659
gopubmedrs10761659
geneviewrs10761659
scholarrs10761659
googlers10761659
pharmgkbrs10761659
gwascentralrs10761659
openSNPrs10761659
23andMers10761659
23andMe allrs10761659
SNP Nexus

SNPshotrs10761659
SNPdbers10761659
MSV3drs10761659
GWAS Ctlgrs10761659
GMAF0.4982
Max Magnitude1
? (A;A) (A;G) (G;G) 28
rs10761659 has been reported in a large study to be associated with Crohn's disease.

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.23 (CI 1.05-1.45), and for homozygotes, 1.55 (CI 1.3-1.84). [PMID 17554300OA-icon.png]


[PMID 19174780] Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort

OMIM612255
DescINFLAMMATORY BOWEL DISEASE 15; IBD15
Variant
Relatedalso
GWAS snp
PMID [PMID 21102463OA-icon.png]
Trait
Title Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
Risk Allele G
P-val 4E-22
Odds Ratio 1.2300 [1.18-1.29]


[PMID 18224312OA-icon.png] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.


[PMID 18438406OA-icon.png] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.


[PMID 18533027OA-icon.png] Worldwide population differentiation at disease-associated SNPs.


[PMID 18853133OA-icon.png] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.


[PMID 18936107] Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients.


[PMID 20846217OA-icon.png] Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.


GET Evidence
rs10761659
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.453125
summary



GWAS snp
PMID [PMID 23128233OA-icon.png]
Trait Inflammatory bowel disease
Title Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Risk Allele G
P-val 6E-46
Odds Ratio 1.17 [1.134-1.20]
GWAS snp
PMID [PMID 22936669]
Trait Crohn's disease
Title A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
Risk Allele G
P-val 5E-6
Odds Ratio 1.28 [NR]