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rs1076560

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 influences working memory
(A;C) 1.3x increased risk for alcoholism
(C;C) 0 normal
ReferenceGRCh38 38.1/141
Chromosome11
Position113412966
GeneDRD2
is asnp
is mentioned by
dbSNPrs1076560
ebirs1076560
HLIrs1076560
Exacrs1076560
Varsomers1076560
Maprs1076560
PheGenIrs1076560
hapmaprs1076560
1000 genomesrs1076560
hgdprs1076560
ensemblrs1076560
gopubmedrs1076560
geneviewrs1076560
scholarrs1076560
googlers1076560
pharmgkbrs1076560
gwascentralrs1076560
openSNPrs1076560
23andMers1076560
23andMe allrs1076560
SNP Nexus

SNPshotrs1076560
SNPdbers1076560
MSV3drs1076560
GWAS Ctlgrs1076560
GMAF0.2149
Max Magnitude2
? (A;A) (A;C) (C;C) 28
Neighborrs1801028
Distance204
Neighborrs1800496
Distance200
rs1076560 is located in intron 6 of the dopamine receptor D2 gene.

In one study of Japanese males, rs1076560(A) alleles were 1.3 fold more associated with Alcoholism than the rs1076560(C) alleles. [PMID 17196743]

The DRD2 risk allele A was more prevalent in the alcoholic patients than in the healthy controls. These data identify rs1076560 as a potentially important variable in the development of alcoholism.

[PMID 19176830OA-icon.png] rs1076560 and the DAT 3'-VNTR variant influences memory

[PMID 19373123] Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution


[PMID 19796663] Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients


[PMID 19940176OA-icon.png] Functional Variation of the Dopamine D2 Receptor Gene Is Associated with Emotional Control as well as Brain Activity and Connectivity during Emotion Processing in Humans



[PMID 19512960] Genetic diagnostics of functional variants of the human dopamine D2 receptor gene


[PMID 20179754OA-icon.png] Genetically Determined Measures of Striatal D2 Signaling Predict Prefrontal Activity during Working Memory Performance


[PMID 19393722OA-icon.png] Genetic contributions to avoidance-based decisions: striatal D2 polymorphisms


[PMID 21087673] D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans


[PMID 21150907OA-icon.png] Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse.


[PMID 22569179] Rs1076560, a functional variant of the dopamine D2 receptor gene, confers risk of schizophrenia in Han Chinese


[PMID 22745721OA-icon.png] Cannabis-Dependence Risk Relates to Synergism between Neuroticism and Proenkephalin SNPs Associated with Amygdala Gene Expression: Case-Control Study


[PMID 18077373OA-icon.png] Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.


[PMID 19321766OA-icon.png] Dopamine DRD2 polymorphism alters reversal learning and associated neural activity.


[PMID 20146828OA-icon.png] Dopamine D2 receptor polymorphisms and susceptibility to alcohol dependence in Indian males: a preliminary study.


[PMID 20617039OA-icon.png] Alcoholism and alternative splicing of candidate genes.


[PMID 21187413OA-icon.png] DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia.


[PMID 21645585] Resting posterior minus frontal EEG slow oscillations is associated with extraversion and DRD2 genotype.


GET Evidence
rs1076560
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.1875
summary



[PMID 24322206] Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain


[PMID 24359476OA-icon.png] The Dopamine Receptor D2 (DRD2) SNP rs1076560 is Associated with Opioid Addiction


[PMID 24424781] DRD2 genotype predicts prefrontal activity during working memory after stimulation of D2 receptors with bromocriptine


[PMID 21976709OA-icon.png] DRD2 genotype-based variation of default mode network activity and of its relationship with striatal DAT binding.