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rs10795668

From SNPedia

Orientationplus
Stabilizedplus
Make rs10795668(A;A)
Make rs10795668(A;G)
Make rs10795668(G;G)
ReferenceGRCh38 38.1/142
Chromosome10
Position8659256
is asnp
is mentioned by
dbSNPrs10795668
ebirs10795668
HLIrs10795668
Exacrs10795668
Varsomers10795668
Maprs10795668
PheGenIrs10795668
hapmaprs10795668
1000 genomesrs10795668
hgdprs10795668
ensemblrs10795668
gopubmedrs10795668
geneviewrs10795668
scholarrs10795668
googlers10795668
pharmgkbrs10795668
gwascentralrs10795668
openSNPrs10795668
23andMers10795668
23andMe allrs10795668
SNP Nexus

SNPshotrs10795668
SNPdbers10795668
MSV3drs10795668
GWAS Ctlgrs10795668
GMAF0.27
Max Magnitude
? (A;A) (A;G) (G;G) 28
rs10795668 is a SNP within chromosomal region 10p14. It has been reported in several publications as being associated with higher risk for colorectal cancer.

In a replication study of ~1,800 Swedish patients, the rs10795668(G) allele was specifically also shown to be associated with younger age of onset for colorectal cancer and with sporadic cases.[PMID 20648012OA-icon.png] Note that this conflicts with the earlier GWAS reports concluding that the risk allele is rs10795668(A).

GWAS
SNP rs10795668
PubMedID [PMID 18372905]
Condition Colorectal cancer
Gene Intergenic
Risk Allele A
pValue 3.00E-013
OR 1.12
95% CI 1.10-1.16


OMIM612230
DescCOLORECTAL CANCER, SUSCEPTIBILITY TO, 5; CRCS5
Variant
Relatedalso

[PMID 19843678] Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort



[PMID 20530476] Risk of Genome-Wide Association Study-Identified Genetic Variants for Colorectal Cancer in a Chinese Population

[PMID 20659471OA-icon.png] Genetic Heterogeneity in Colorectal Cancer Associations in Americans of African vs. European Descent

[PMID 21097774] Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome

[PMID 21119214OA-icon.png] Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters

[PMID 21179028OA-icon.png] Replication study of SNP associations for colorectal cancer in Hong Kong Chinese


[PMID 22367214OA-icon.png] Characterization of gene-environment interactions for colorectal cancer susceptibility loci


[PMID 22363440OA-icon.png] cis-Expression QTL Analysis of Established Colorectal Cancer Risk Variants in Colon Tumors and Adjacent Normal Tissue


[PMID 22457859] Single nucleotide polymorphisms in colorectal cancer: associations with tumor site and TNM stage


[PMID 19011631OA-icon.png] Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.


[PMID 20501757OA-icon.png] Low-penetrance susceptibility variants in familial colorectal cancer.


[PMID 21071539OA-icon.png] Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.


[PMID 21314996OA-icon.png] Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.


[PMID 21402474] GWAS-identified colorectal cancer susceptibility locus associates with disease prognosis.


[PMID 22045029] Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.


[PMID 22235025] Susceptibility genetic variants associated with early-onset colorectal cancer.


GET Evidence
rs10795668
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.273438
summary



[PMID 23359760OA-icon.png] Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population


[PMID 23712746] GENETIC SUSCEPTIBILITY VARIANTS ASSOCIATED WITH COLORECTAL CANCER PROGNOSIS


[PMID 23717594OA-icon.png] The Genetic Variant on Chromosome 10p14 Is Associated with Risk of Colorectal Cancer: Results from a Case-Control Study and a Meta-Analysis


[PMID 23875689] Colorectal Cancer-Susceptibility Single Nucleotide Polymorphisms in Korean Population


[PMID 22848671OA-icon.png] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.


[PMID 22999960OA-icon.png] Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.


[PMID 23434150OA-icon.png] Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?


[PMID 24801760OA-icon.png] Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP


[PMID 24875374OA-icon.png] Variation in the Association Between Colorectal Cancer Susceptibility Loci and Colorectal Polyps by Polyp Type

GWAS snp
PMID [PMID 24836286OA-icon.png]
Trait Colorectal cancer
Title Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
Risk Allele G
P-val 5E-15
Odds Ratio 1.15 [1.11-1.19]


[PMID 24727911OA-icon.png] Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer