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rs1080985

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0.1 a common variant
(C;G) 0.1 a common variant
(G;G) Homozygous for CYP2D6 variants (non-CYP2D6*1)
ReferenceGRCh37 37.1/132
Chromosome22
Position42528382
GeneCYP2D6
is asnp
is mentioned by
dbSNPrs1080985
ebirs1080985
HLIrs1080985
Exacrs1080985
Varsomers1080985
Maprs1080985
PheGenIrs1080985
hapmaprs1080985
1000 genomesrs1080985
hgdprs1080985
ensemblrs1080985
gopubmedrs1080985
geneviewrs1080985
scholarrs1080985
googlers1080985
pharmgkbrs1080985
gwascentralrs1080985
openSNPrs1080985
23andMers1080985
23andMe allrs1080985
SNP Nexus

SNPshotrs1080985
SNPdbers1080985
MSV3drs1080985
GWAS Ctlgrs1080985
GMAF0.1699
Max Magnitude0.1

rs1080985 is a SNP near the CYP2D6 gene. Depending on the publication source, it may be called "-1584C/G" or "1496C>G" or the like.

The wild type (normal) allele at this SNP is (C). The (G) variant indicates the presence of a non-wild type CYP2D6 variant, but it appears in many different variants so it can not be used to determine the presence of any particular variant.

The rs1080985(G) allele defines the CYP2D6*2A variant, which has been reported to have relatively normal function yet in some cases may also lead to the intermediate metabolism phenotype.[PMID 11037799]


[PMID 19604081] Relevance of CYP2D6 -1584C>G polymorphism for thioridazine:mesoridazine plasma concentration ratio in psychiatric patients

[PMID 19738170OA-icon.png] Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease

Please be careful when interpreting results for this SNP as it is in dbSNP and SNPedia in minus orientation where the risk allele is G, but test results are usually in plus orientation where the risk allele is C. This SNP has an ambiguous flip which can make this very confusing.

[PMID 18547414OA-icon.png] Genotyping panel for assessing response to cancer chemotherapy.

[PMID 22465999] Replication Study to Confirm the Role of CYP2D6 Polymorphism rs1080985 on Donepezil Efficacy in Alzheimer's Disease Patients.


[PMID 22688145] Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters


[PMID 23133420OA-icon.png] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.