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rs10830963

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal risk of Type-2 Diabetes
(C;G) 2.7 increased type-2 diabetes risk; higher gestational diabetes risk
(G;G) 3.1 increased type-2 diabetes risk; higher gestational diabetes risk
ReferenceGRCh38 38.1/141
Chromosome11
Position92975544
GeneMTNR1B
is asnp
is mentioned by
dbSNPrs10830963
ebirs10830963
HLIrs10830963
Exacrs10830963
Varsomers10830963
Maprs10830963
PheGenIrs10830963
hapmaprs10830963
1000 genomesrs10830963
hgdprs10830963
ensemblrs10830963
gopubmedrs10830963
geneviewrs10830963
scholarrs10830963
googlers10830963
pharmgkbrs10830963
gwascentralrs10830963
openSNPrs10830963
23andMers10830963
23andMe allrs10830963
SNP Nexus

SNPshotrs10830963
SNPdbers10830963
MSV3drs10830963
GWAS Ctlgrs10830963
GMAF0.258
Max Magnitude3.1
? (C;C) (C;G) (G;G) 28
[PMID 19241057] rs10830963 was associated with an increased risk of type-2 diabetes in our Han Chinese cohort (OR 1.16, 95% CI 1.03-1.31, p = 0.015). As previously described, the risk variant was also associated with increased fasting plasma glucose, showing an increase of 0.068 mmol/l (95% CI 0.036-0.100, p = 4 x 10(-5)) per risk allele

[PMID 19088850OA-icon.png] rs10830962, rs4753426, and rs10830963 were significantly associated with higher fasting plasma glucose concentrations and reduced OGTT- and IVGTT-induced insulin release. rs3781638 displayed significant association with lower fasting plasma glucose levels and increased OGTT-induced insulin release

[PMID 19324940OA-icon.png] A study totaling 19,000+ Europeans concluded that rs10830963 had the most influence of any MTNR1B gene SNP on the risk for type-2 diabetes. Specifically, the (G) allele increased the risk of isolated impaired fasting glycemia (OR=1.64, P=5.5x10(-11)) but not isolated impaired glucose tolerance.

[PMID 21658282OA-icon.png] 900+ patients with gestational diabetes were studied, and the rs10830963(G) SNP was postulated to perhaps be a causal SNP for the condition, with an odds ratio of ~1.3 - 1.4.

GWAS snp
PMID [PMID 19060907OA-icon.png]
Trait Fasting plasma glucose
Title Variants in MTNR1B influence fasting glucose levels
Risk Allele G
P-val 3E-50
Odds Ratio 0.07 [0.06-0.08] mmol/l increase


[PMID 19651812OA-icon.png] Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type-2 diabetes amongst Indian Asians and European whites

[PMID 19741166OA-icon.png] Common Genetic Determinants of Glucose Homeostasis in Healthy Children: The European Youth Heart Study (EYHS)


GWAS snp
PMID [PMID 20081858OA-icon.png]
Trait Fasting glucose-related traits
Title New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Risk Allele G
P-val 0
Odds Ratio None None


[PMID 20536959] Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort

[PMID 20802253OA-icon.png] Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion

[PMID 20839289OA-icon.png] Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose


[PMID 21036910OA-icon.png] Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study

[PMID 21059861] Association of a melatonin receptor 1B (MTNR1B) gene variant with fasting glucose and HOMA-B in children and adolescents of high BMI-SDS groups

OMIM613233
Desc
Variant
Relatedalso
[PMID 21470412OA-icon.png] A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals


[PMID 21949744OA-icon.png] Effects of 16 Genetic Variants on Fasting Glucose and Type 2 Diabetes in South Asians: ADCY5 and GLIS3 Variants May Predispose to Type 2 Diabetes


[PMID 22096510OA-icon.png] Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a chinese population


[PMID 22450346] The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population


[PMID 22508271OA-icon.png] Fasting Glucose GWAS Candidate Region Analysis Across Ethnic Groups in the Multiethnic Study of Atherosclerosis (MESA).


[PMID 22698518] Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients


[PMID 22768333OA-icon.png] Association of Genetic Variants of Melatonin Receptor 1B with Gestational Plasma Glucose Level and Risk of Glucose Intolerance in Pregnant Chinese Women

GWAS snp
PMID [PMID 22286219OA-icon.png]
Trait
Title Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
Risk Allele
P-val 3E-11
Odds Ratio 0.1400 None


[PMID 22768041OA-icon.png] Allele Summation of Diabetes Risk Genes Predicts Impaired Glucose Tolerance in Female and Obese Individuals


[PMID 19184136OA-icon.png] Examination of association of genes in the serotonin system to autism.


[PMID 19324937OA-icon.png] Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.


[PMID 19455304OA-icon.png] Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response.


[PMID 19502414OA-icon.png] Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.


[PMID 19533084OA-icon.png] Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.


[PMID 19822575OA-icon.png] Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing.


[PMID 19937311] Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.


[PMID 20043853OA-icon.png] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.


[PMID 20152958OA-icon.png] A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels.


[PMID 20398260OA-icon.png] MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai.


[PMID 20628598OA-icon.png] Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.


[PMID 20664687OA-icon.png] Single-nucleotide polymorphisms in chromosome 3p14.1- 3p14.2 are associated with susceptibility of type 2 diabetes with cataract.


[PMID 20668700OA-icon.png] Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion.


[PMID 20712903OA-icon.png] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.


[PMID 20870969OA-icon.png] Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study.


[PMID 20959387] Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome.


[PMID 21278902OA-icon.png] Genetic risk profiling for prediction of type 2 diabetes.


[PMID 21366812] Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents.


[PMID 21380592] No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 diabetes: results from the Nord-Trondelag Health Study.


[PMID 21558052OA-icon.png] A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: Genetic risk is modulated by obesity.


[PMID 21711391] Association and evolutionary studies of the melatonin receptor 1B gene (MTNR1B) in the self-contained population of Sorbs from Germany.


[PMID 22377712] Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.

GWAS snp
PMID [PMID 22581228OA-icon.png]
Trait
Title A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
Risk Allele
P-val 4E-105
Odds Ratio None None


GET Evidence
rs10830963
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.203125
summary



[PMID 22759724] Polymorphisms in the melatonin receptor 1B gene and the risk of delirium


[PMID 23029294OA-icon.png] Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus


[PMID 23690305OA-icon.png] Genetic variants and the risk of gestational diabetes mellitus: a systematic review


[PMID 23840762OA-icon.png] Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk


[PMID 24005634] [Involvement of melatonin MT2 receptor mutants in type 2 diabetes development]


[PMID 24157813] Association between Genetic Variations in MTNR1A and MTNR1B Genes and Gestational Diabetes Mellitus in Han Chinese Women


[PMID 23092954OA-icon.png] SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.


[PMID 23456907OA-icon.png] Maternal genotype and gestational diabetes.


[PMID 23462794OA-icon.png] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.


[PMID 23611530] Genetics of melatonin receptor type 2 is associated with left ventricular function in hypertensive patients treated according to guidelines.


[PMID 25132852OA-icon.png] MTNR1B Genetic Variability Is Associated with Gestational Diabetes in Czech Women

GWAS snp
PMID [PMID 24509480OA-icon.png]
Trait Type 2 diabetes
Title Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Risk Allele G
P-val 2E-7
Odds Ratio 1.11 [1.06-1.16]
GWAS snp
PMID [PMID 23251661OA-icon.png]
Trait Obesity-related traits
Title Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Risk Allele G
P-val 4E-8
Odds Ratio .05 [NR] mg/dL increase


[PMID 25707907] Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study


[PMID 25898821] The polymorphisms of melatonin receptor 1B gene (MTNR1B) (rs4753426 and rs10830963) and susceptibility to adolescent idiopathic scoliosis: a meta-analysis


[PMID 26440713] Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans


[PMID 26519818] Family association study between melatonin receptor gene polymorphisms and polycystic ovary syndrome in Han Chinese


[PMID 26551672] Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.


[PMID 26563312] Relationship between melatonin receptor 1B (rs10830963 and rs1387153) with gestational diabetes mellitus: a case-control study and meta-analysis


[PMID 26912228] Insomnia does not mediate or modify the association between MTNR1B risk variant rs10830963 and glucose levels.


[PMID 27763686] Melatonin and the pathologies of weakened or dysregulated circadian oscillators.