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rs10838738

From SNPedia

Orientationplus
Stabilizedplus
Make rs10838738(A;A)
Make rs10838738(A;G)
Make rs10838738(G;G)
ReferenceGRCh38 38.1/141
Chromosome11
Position47641497
GeneMTCH2
is asnp
is mentioned by
dbSNPrs10838738
ebirs10838738
HLIrs10838738
Exacrs10838738
Varsomers10838738
Maprs10838738
PheGenIrs10838738
hapmaprs10838738
1000 genomesrs10838738
hgdprs10838738
ensemblrs10838738
gopubmedrs10838738
geneviewrs10838738
scholarrs10838738
googlers10838738
pharmgkbrs10838738
gwascentralrs10838738
openSNPrs10838738
23andMers10838738
23andMe allrs10838738
SNP Nexus

SNPshotrs10838738
SNPdbers10838738
MSV3drs10838738
GWAS Ctlgrs10838738
GMAF0.2837
Max Magnitude
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 19079261OA-icon.png]
Trait Body mass index
Title Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Risk Allele G
P-val 5E-9
Odds Ratio 0.07 [0.01-0.13] kg/m2 increase


OMIM613221
DescMITOCHONDRIAL CARRIER HOMOLOG 2; MTCH2
Variant
Relatedalso


[PMID 21248185] Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals


[PMID 21796141] Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area


[PMID 21912638OA-icon.png] Studies of metabolic phenotypic correlates of 15 obesity associated gene variants


[PMID 22083549] Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty

[PMID 19474294OA-icon.png] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

[PMID 19478790OA-icon.png] The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.

[PMID 19526209OA-icon.png] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

[PMID 19553259OA-icon.png] Common body mass index-associated variants confer risk of extreme obesity.

[PMID 19910641OA-icon.png] Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus.

[PMID 19910938] Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.

[PMID 20127379OA-icon.png] From monogenic to polygenic obesity: recent advances.

[PMID 20712903OA-icon.png] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.

[PMID 20824172OA-icon.png] Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.

[PMID 21283731OA-icon.png] FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.

[PMID 22179955OA-icon.png] Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.


GET Evidence
rs10838738
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.25
summary



Measures of Obesity