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rs10893081

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 2x increased risk for severe atherosclerosis; 1.2x increased risk for ischemic heart disease
(C;T) normal
(T;T) normal
ReferenceGRCh38 38.1/141
Chromosome11
Position123742322
GeneZNF202
is asnp
is mentioned by
dbSNPrs10893081
ebirs10893081
HLIrs10893081
Exacrs10893081
Varsomers10893081
Maprs10893081
PheGenIrs10893081
hapmaprs10893081
1000 genomesrs10893081
hgdprs10893081
ensemblrs10893081
gopubmedrs10893081
geneviewrs10893081
scholarrs10893081
googlers10893081
pharmgkbrs10893081
gwascentralrs10893081
openSNPrs10893081
23andMers10893081
23andMe allrs10893081
SNP Nexus

SNPshotrs10893081
SNPdbers10893081
MSV3drs10893081
GWAS Ctlgrs10893081
GMAF0.3595
Max Magnitude
rs10893081 is a SNP in the promoter region upstream of the ZNF202 gene. This SNP is also known as -660A>G SNP of this gene (note orientation as discussed often varies from the orientation in dbSNP).

Based on (1) a cross-sectional study of 5,355 Danish individuals with regard to severe atherosclerosis, (2) 10,431 Danish individuals with regard to ischemic heart disease (IHD), and (3) verification in 2 independent case-control studies including, respectively, 942 and 1,549 cases with IHD and 8,998 controls, rs10893081 was associated with risk. Specifically, rs10893081(C;C) yielded an odds ratio for severe atherosclerosis of 2.01 (CI: 1.34 to 3.01), and prospectively, a hazard ratio for IHD of 1.21 (CI: 1.02 to 1.43).[PMID 18652945]