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rs10895068

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 1.5 2.5x increased odds of breast cancer among hormone-using postmenopausal women
(A;G) 1.5 2.5x increased odds of breast cancer among hormone-using postmenopausal women
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome11
Position101129483
GeneLOC101054525, PGR
is asnp
is mentioned by
dbSNPrs10895068
ebirs10895068
HLIrs10895068
Exacrs10895068
Varsomers10895068
Maprs10895068
PheGenIrs10895068
hapmaprs10895068
1000 genomesrs10895068
hgdprs10895068
ensemblrs10895068
gopubmedrs10895068
geneviewrs10895068
scholarrs10895068
googlers10895068
pharmgkbrs10895068
gwascentralrs10895068
openSNPrs10895068
23andMers10895068
23andMe allrs10895068
SNP Nexus

SNPshotrs10895068
SNPdbers10895068
MSV3drs10895068
GWAS Ctlgrs10895068
GMAF0.02066
Max Magnitude1.5
rs10895068, also known as +331G/A, is a SNP in the progesterone receptor PGR gene.

A study of 1,664 postmenopausal breast cancer cases and 2,391 controls led to two conclusions. First, women with at least one rs10895068(A) allele had a 1.3x (CI: 1.04-1.65) increased risk of developing breast cancer. Second, such carriers were at 2.57x (CI: 1.64-4.02) increased risk for breast cancer if they were never postmenopausal hormone users.[PMID 19462450OA-icon.png]

2013 meta-analysis suggested association of weak effect with female reproductive (breast, endometrial and ovarian) cancer for A allele (A: OR = 1.063, 95% CI = 1.001-1.129; AA+AG: OR = 1.067, 95% CI = 1.002-1.136). A 2014 meta-analysis that looked only for association with ovarian cancer specifically found no significant association between rs10895068 and ovarian cancer - despite the study title claiming otherwise.

[PMID 24197980] Progesterone receptor PROGINS and +331G/A polymorphisms confer susceptibility to ovarian cancer: a meta-analysis based on 17 studies.

[PMID 23349706OA-icon.png] Association of +331G/A PgR polymorphism with susceptibility to female reproductive cancer: evidence from a meta-analysis.


[PMID 20076999] No association between a progesterone receptor gene promoter polymorphism (+331G>A) and breast cancer risk in Caucasian women: evidence from a literature-based meta-analysis


[PMID 20586553] Polymorphisms in ESR1, ESR2 and HSD17B1 genes are associated with fertility status in endometriosis

[PMID 21086036OA-icon.png] Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population

[PMID 21148628OA-icon.png] Progesterone receptor gene variants and risk of endometrial cancer

? (A;G) (G;G)


[PMID 22121098] Worldwide distribution of allelic variation at the progesterone receptor locus and the incidence of female reproductive cancers


[PMID 16614108] Association of the progesterone receptor gene with breast cancer risk: a single-nucleotide polymorphism tagging approach.


[PMID 16985038] PGR +331 A/G and increased risk of epithelial ovarian cancer.


[PMID 17592773] Progesterone receptor polymorphisms and risk of breast cancer: results from two Australian breast cancer studies.


[PMID 18219286OA-icon.png] Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis.


[PMID 18592033OA-icon.png] Sex steroid-related candidate genes in psychiatric disorders.


[PMID 18628428OA-icon.png] Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.


[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.


[PMID 19382201OA-icon.png] Association of the progesterone receptor gene with endometrial cancer risk in a Chinese population.


[PMID 19555469OA-icon.png] A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis.


[PMID 26694100] Obesity-related known and candidate SNP markers can significantly change affinity of TATA-binding protein for human gene promoters.