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rs10980705

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 1 Normal risk for knee osteoarthritis
(C;T) 1.5 2.3x increased risk for knee osteoarthritis
(T;T) 2 3.7x increased risk for knee osteoarthritis
ReferenceGRCh38 38.1/141
Chromosome9
Position111040905
GeneLPAR1
is asnp
is mentioned by
dbSNPrs10980705
ebirs10980705
HLIrs10980705
Exacrs10980705
Varsomers10980705
Maprs10980705
PheGenIrs10980705
hapmaprs10980705
1000 genomesrs10980705
hgdprs10980705
ensemblrs10980705
gopubmedrs10980705
geneviewrs10980705
scholarrs10980705
googlers10980705
pharmgkbrs10980705
gwascentralrs10980705
openSNPrs10980705
23andMers10980705
23andMe allrs10980705
SNP Nexus

SNPshotrs10980705
SNPdbers10980705
MSV3drs10980705
GWAS Ctlgrs10980705
GMAF0.1924
Max Magnitude2
? (C;C) (C;T) (T;T) 28
rs10980705, also known as -2820G/A, is a SNP upstream of the lysophosphatidic acid receptor 1 LPAR1 gene.

In a study of 2 Japanese populations of patients with knee osteoarthritis (OA), the rs10980705(T) allele (in dbSNP orientation) was associated with increased risk in two Japanese populations, with an odds ratio of 2.3 (CI: 1.6-3.3, p=2.6x10-5). The association appears to hold only for the homozygous (T;T) genotype, and the authors state they believe this variant may be the "disease-causing SNP". However, 2% of individuals without knee OA are (T;T) homozygotes, and, over 50% of all patients with knee OA are (C;C) homozygotes.[PMID 18325907]

In a study of five collections of samples, and a meta-analysis combining them all, no particularly significant association was seen for rs10980705 with either knee OA or hip OA. These authors conclude it's either a weak effect (and more people need to be studied), or perhaps it's a phenomena more relevant to Asians than to Europeans.[PMID 18625619]

OMIM602282
DescLYSOPHOSPHATIDIC ACID RECEPTOR 1; LPAR1
Variant
Relatedalso
OMIM165720
Desc
Variant
Relatedalso