From SNPedia
| Genotype | Effect |
|---|
| rs11045585(A;A) | 24% chance (lower than average) of docetaxel-induced leukopenia/neutropenia |
| rs11045585(A;G) | 63% chance (higher than average) of docetaxel-induced leukopenia/neutropenia |
| rs11045585(G;G) | (no data; implied high chance of docetaxel-induced leukopenia/neutropenia) |
[PMID 18294295] rs12762549 and rs11045585 can be used to predict whether docetaxel will induce leukopenia/neutropenia, according to a study of ~100 Japanese patients. When patients were classified into three groups by the scoring system based on the genotypes of these two SNPs, patients with a score of 1 or 2 were shown to have a significantly higher risk of docetaxel-induced leukopenia/neutropenia as compared to those with a score of 0 (P = 0.0000057; odds ratio [OR], 7.00; 95% CI [confidence interval], 2.95-16.59). This prediction system correctly classified 69.2% of severe leukopenia/neutropenia and 75.7% of non-leukopenia/neutropenia into the respective categories.
[Effect percentages provided in table are raw population fractions taken from the referenced study based on rs11045585 only. Total population size = 113. Breakdown: leukopenia/neutropenia: AA=20 AG=19; non-leukopenia/neutropenia: AA=63 AG=11]
| ? | (A;A) (A;G) (G;G) |
|---|
 |
| PharmGKB | PA162191295 |
| Name | |
| Annotation | A case-control association study in 84 patients who received docetaxel chemotherapy found a significant association of rs11045585 in SLCO1B3 with docetaxel-induced leukopenia/neutropenia. |
| Gene | SLCO1B3 |
| Featue | |
| Evidence | PubMed ID:18294295 |
| Drugs | docetaxel |
| Diseases | Leukopenia, Neutropenia |
| Curation Level | Curated |
