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rs11045879

From SNPedia

Orientationplus
Stabilizedplus
Make rs11045879(C;C)
Make rs11045879(C;T)
Make rs11045879(T;T)
ReferenceGRCh38 38.1/141
Chromosome12
Position21229685
GeneSLCO1B1
is asnp
is mentioned by
dbSNPrs11045879
ebirs11045879
HLIrs11045879
Exacrs11045879
Varsomers11045879
Maprs11045879
PheGenIrs11045879
hapmaprs11045879
1000 genomesrs11045879
hgdprs11045879
ensemblrs11045879
gopubmedrs11045879
geneviewrs11045879
scholarrs11045879
googlers11045879
pharmgkbrs11045879
gwascentralrs11045879
openSNPrs11045879
23andMers11045879
23andMe allrs11045879
SNP Nexus

SNPshotrs11045879
SNPdbers11045879
MSV3drs11045879
GWAS Ctlgrs11045879
GMAF0.2525
Max Magnitude
? (C;C) (C;T) (T;T) 28
[PMID 19901119OA-icon.png] Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects



[PMID 21387541] Polymorphisms of the SLCO1B1 gene predict methotrexate-related toxicity in childhood acute lymphoblastic leukemia

[PMID 19419973OA-icon.png] Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.


GET Evidence
rs11045879
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.174603
summary



GWAS snp
PMID [PMID 23281178]
Trait Metabolite levels
Title A genome-wide assessment of variability in human serum metabolism.
Risk Allele C
P-val 5E-15
Odds Ratio NR NR


[PMID 23222202] Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia.


[PMID 25098908] Influence of the folate pathway and transporter polymorphisms on methotrexate treatment outcome in osteosarcoma