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rs11203366

From SNPedia

Orientationplus
Stabilizedplus
Make rs11203366(A;A)
Make rs11203366(A;G)
Make rs11203366(G;G)
ReferenceGRCh38 38.1/141
Chromosome1
Position17331039
GenePADI4
is asnp
is mentioned by
dbSNPrs11203366
ebirs11203366
HLIrs11203366
Exacrs11203366
Varsomers11203366
Maprs11203366
PheGenIrs11203366
hapmaprs11203366
1000 genomesrs11203366
hgdprs11203366
ensemblrs11203366
gopubmedrs11203366
geneviewrs11203366
scholarrs11203366
googlers11203366
pharmgkbrs11203366
gwascentralrs11203366
openSNPrs11203366
23andMers11203366
23andMe allrs11203366
SNP Nexus

SNPshotrs11203366
SNPdbers11203366
MSV3drs11203366
GWAS Ctlgrs11203366
GMAF0.4486
Max Magnitude
? (A;A) (A;G) (G;G) 28
Venter snp
Source plos
Gene PADI4
allele A
frequency 0.417
sift TOLERATED
HuRef 1103675033959
Disease Association PADI4 is thought to be a rheumatoid arthritis susceptibility locus (MIM:180300). Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.



Neighborrs11203367
Distance82


[PMID 20563870] The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population

[PMID 18576335OA-icon.png] Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis.

[PMID 20537173OA-icon.png] Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study.

[PMID 21039740] PADI4 gene polymorphism is not associated with ankylosing spondylitis in Chinese Han population.


[PMID 22976394] Association of single nucleotide polymorphisms (SNPs) of PADI4 gene with rheumatoid arthritis (RA) in Indian population


GET Evidence
PADI4-G55S
aa_change Gly55Ser
aa_change_short G55S
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.54406
summary



[PMID 23450494] [Association of polymorphisms of PTPN22 and PADI4 genes with rheumatoid arthritis in Yunnan]