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rs11203367

From SNPedia

Orientationplus
Stabilizedplus
Make rs11203367(C;C)
Make rs11203367(C;T)
Make rs11203367(T;T)
ReferenceGRCh38 38.1/141
Chromosome1
Position17331121
GenePADI4
is asnp
is mentioned by
dbSNPrs11203367
ebirs11203367
HLIrs11203367
Exacrs11203367
Varsomers11203367
Maprs11203367
PheGenIrs11203367
hapmaprs11203367
1000 genomesrs11203367
hgdprs11203367
ensemblrs11203367
gopubmedrs11203367
geneviewrs11203367
scholarrs11203367
googlers11203367
pharmgkbrs11203367
gwascentralrs11203367
openSNPrs11203367
23andMers11203367
23andMe allrs11203367
SNP Nexus

SNPshotrs11203367
SNPdbers11203367
MSV3drs11203367
GWAS Ctlgrs11203367
GMAF0.4421
Max Magnitude
? (C;C) (C;T) (T;T) 28
Rs11203367
PubMed [PMID 12833157]
Affy Probeset SNP_A-1912716
Affy Orientation reverse
On GW 5.0 0
Alleles A/B A/G
Ancestral C
Population Japan
Allele T
Case Freq.
Control Freq.
Odds Ratio Het
Odds Ratio Hom
Odds Ratio All 1.97
Disease Rheumatoid Arthritis (RA)


rs11203367 increases susceptibility to Rheumatoid Arthritis 1.26 times for carriers of the T allele [PMID 17265154]

rs11203367 increases susceptibility to Rheumatoid Arthritis 1.50 times for carriers of the T allele [PMID 17265154]

rs11203367 increases susceptibility to Rheumatoid Arthritis 1.97 times for carriers of the T allele [PMID 12833157]

Venter snp
Source plos
Gene PADI4
allele C
frequency 0.414
sift TOLERATED
HuRef 1103675033958
Disease Association PADI4 is thought to be a rheumatoid arthritis susceptibility locus (MIM:180300). Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.


Neighborrs11203366
Distance82


[PMID 20563870] The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population


[PMID 18576335OA-icon.png] Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis.


[PMID 18794853OA-icon.png] Common variants at CD40 and other loci confer risk of rheumatoid arthritis.


[PMID 20537173OA-icon.png] Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study.


[PMID 21039740] PADI4 gene polymorphism is not associated with ankylosing spondylitis in Chinese Han population.


[PMID 22976394] Association of single nucleotide polymorphisms (SNPs) of PADI4 gene with rheumatoid arthritis (RA) in Indian population


GET Evidence
PADI4-V82A
aa_change Val82Ala
aa_change_short V82A
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.552333
summary



[PMID 27182695] PADI4 Polymorphisms in Iranian Patients with Rheumatoid Arthritis.