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rs11209032

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.3x higher risk for spondylitis
(A;G) 1.3x higher risk for spondylitis
(G;G) 0 normal risk
ReferenceGRCh38 38.1/141
Chromosome1
Position67274409
GeneIL23R
is asnp
is mentioned by
dbSNPrs11209032
ebirs11209032
HLIrs11209032
Exacrs11209032
Varsomers11209032
Maprs11209032
PheGenIrs11209032
hapmaprs11209032
1000 genomesrs11209032
hgdprs11209032
ensemblrs11209032
gopubmedrs11209032
geneviewrs11209032
scholarrs11209032
googlers11209032
pharmgkbrs11209032
gwascentralrs11209032
openSNPrs11209032
23andMers11209032
23andMe allrs11209032
SNP Nexus

SNPshotrs11209032
SNPdbers11209032
MSV3drs11209032
GWAS Ctlgrs11209032
GMAF0.3223
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs11209032 is one of several SNPs in the IL23R gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with ankylosing spondylitis. The odds ratio is 1.3 (p=7.5x10e-9).[PMID 17952073, PMID 18037607]

[PMID 18713787] rs11209032 and rs1495965 no significant association with systemic sclerosis


[PMID 19034457] Lack of association between interleukin 23 receptor gene polymorphisms and rheumatoid arthritis susceptibility


[PMID 20375120] IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population

[PMID 19690863] Single-nucleotide polymorphisms and expression of IL23R in Chinese ankylosing spondylitis patients

OMIM106300
Desc
Variant
Relatedalso


[PMID 22089529] Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis


[PMID 17068223OA-icon.png] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.


[PMID 17678723] Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort.


[PMID 17786191OA-icon.png] rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.


[PMID 18470928OA-icon.png] IL23R haplotypes provide a large population attributable risk for Crohn's disease.


[PMID 18853133OA-icon.png] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.


[PMID 19175939OA-icon.png] IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.


[PMID 19189980] Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta-analysis of published series.


[PMID 19306001] No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus.


[PMID 19522770] Variants of the IL23R gene are associated with ankylosing spondylitis but not with Sjogren syndrome in Hungarian population samples.


[PMID 19757086] Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients.


[PMID 19849816OA-icon.png] Genetics of rheumatic disease.


[PMID 20116410] Polymorphisms of IL23R and Vogt-Koyanagi-Harada syndrome in a Chinese Han population.


[PMID 20454450OA-icon.png] Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.


[PMID 21253733] Interleukin-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.


[PMID 21304977OA-icon.png] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.


[PMID 23093364] Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn's disease and psoriasis


[PMID 23840727OA-icon.png] IL23R Gene Confers Susceptibility to Ankylosing Spondylitis Concomitant with Uveitis in a Han Chinese Population


[PMID 24151497OA-icon.png] Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria


[PMID 23564312] Polymorphisms of the IL-23R gene are associated with primary immune thrombocytopenia but not with the clinical outcome of pulsed high-dose dexamethasone therapy.


[PMID 24998354] Determination of IL-23 receptor gene polymorphism in Iranian patients with ankylosing spondylitis


[PMID 26916345] An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.