From SNPedia
rs1121980, a SNP in the
FTO gene, showed the strongest association of several SNPs in the region with early onset
obesity in a study of ~1,000 Caucasians.
The odds ratio for the rs1121980(T) risk allele was 1.66 (CI: 1.37–2.01); and the odds ratios for heterozygotes and homozygotes (rs1121980(T;T)) were estimated (with a correct p<0.0001) at 1.67 (CI: 1.22–2.27) and 2.76 (CI: 1.88–4.03), respectively. [PMID 18159244]
Note that although rs1121980 showed the strongest association, it is in a block in the FTO gene of at least 5 other SNPs that are in linkage disequilibrium (r2>=0.88 for all). The other 5 SNPs are:
[PMID 18379722] This SNP is also associated with (severe) obesity in a study of 927 Japanese patients.
[PMID 19164386] obesity and type-2 diabetes
| ? | (C;C) (C;T) (T;T) |
|---|
 |
| GWAS snp
|
| PMID
| [PMID 18454148]
|
| Trait
| Body mass index
|
| Title
| Common variants near MC4R are associated with fat mass, weight and risk of obesity
|
| Risk Allele
|
|
| P-val
| 4.0000000000000001E-8
|
| Odds Ratio
| 0.06 [0.04-0.08] unit increase in log(BMI)
|
[PMID 19322589] Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study
[PMID 19553294] Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene
Related to BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 14; BMIQ14
according to
omim 612460. See
also
| PharmGKB | PA164740861 |
| Name | |
| Annotation | GWAS results: Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants. (Initial Sample Size: 487 young cases, 442 controls; Replication Sample Size: 2,269 individuals in 644 families); (Region: 16q12.2; Reported Gene(s): FTO; Risk Allele: rs1121980-T); (p-value= 9.99999999999999E-08).This variant is associated with Obesity (early onset extreme). |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:18159244; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Obesity |
| Curation Level | Non-Curated |
[PMID 19812171] Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
[PMID 20075932] Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese
