|(C;T)||2.5||1.67x risk for obesity|
|(T;T)||3||2.76x risk for obesity|
The odds ratio for the rs1121980(T) risk allele was 1.66 (CI: 1.37â€“2.01); and the odds ratios for heterozygotes and homozygotes (rs1121980(T;T)) were estimated (with a correct p<0.0001) at 1.67 (CI: 1.22â€“2.27) and 2.76 (CI: 1.88â€“4.03), respectively. [PMID 18159244]
Note that although rs1121980 showed the strongest association, it is in a block in the FTO gene of at least 5 other SNPs that are in linkage disequilibrium (r2>=0.88 for all). The other 5 SNPs are:
|Trait||Body mass index|
|Title||Common variants near MC4R are associated with fat mass, weight and risk of obesity|
|Odds Ratio||0.06 [0.04-0.08] unit increase in log(BMI)|
[PMID 19322589] Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study
[PMID 19553294] Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene
[PMID 19812171] Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
[PMID 20075932] Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese
[PMID 22355368] Longitudinal Replication Studies of GWAS Risk SNPs Influencing Body Mass Index over the Course of Childhood and Adulthood
[PMID 21248185] Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals
[PMID 18256137] Regulation of Fto/Ftm gene expression in mice and humans.
[PMID 18487448] Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population.
[PMID 18599522] FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.
[PMID 19079261] Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
[PMID 19474294] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
[PMID 20017965] Identifying association under a previous linkage peak on chromosome 16 for body mass index using cross-sectional and longitudinal data of the Framingham Heart Study.
[PMID 20017980] A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data.
[PMID 20018076] Tests for candidate-gene interaction for longitudinal quantitative traits measured in a large cohort.
[PMID 20299471] FTO genetic variation and association with obesity in West Africans and African Americans.
[PMID 20442772] Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.
[PMID 20824172] Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.
[PMID 21102551] Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort.
[PMID 21115529] Genetics and genomics of human ageing.
[PMID 22049296] A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23935507] Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry
[PMID 24106974] Association between fat mass and obesity-associated (FTO) gene and hip fracture susceptibility
|Title||Discovery and refinement of loci associated with lipid levels.|
|Odds Ratio||.02 [NR] unit decrease|
[PMID 26445370] Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status - The HUNT Study
[PMID 26726774] Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans.
[PMID 26843521] A comprehensive meta-analysis of case-control association studies to evaluate polymorphisms associated with the risk of differentiated thyroid carcinoma.
[PMID 26935496] The Frequencies of Haplotypes of FTO Gene Variants and Their Association with the Distribution of Body Fat in Non-Obese Poles.
[PMID 27820839] FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men.