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rs1128535

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0.5 normal
(A;G) 1.8 0.77x risk for Crohn's disease
(G;G) 2 reduced risk (0.77x) for Crohn's disease
ReferenceGRCh38 38.1/141
Chromosome3
Position49828959
GeneTRAIP
is asnp
is mentioned by
dbSNPrs1128535
ebirs1128535
HLIrs1128535
Exacrs1128535
Varsomers1128535
Maprs1128535
PheGenIrs1128535
hapmaprs1128535
1000 genomesrs1128535
hgdprs1128535
ensemblrs1128535
gopubmedrs1128535
geneviewrs1128535
scholarrs1128535
googlers1128535
pharmgkbrs1128535
gwascentralrs1128535
openSNPrs1128535
23andMers1128535
23andMe allrs1128535
SNP Nexus

SNPshotrs1128535
SNPdbers1128535
MSV3drs1128535
GWAS Ctlgrs1128535
GMAF0.393
Max Magnitude2
? (A;A) (A;G) (G;G) 28
The less common allele of rs1128535, a SNP in the TRAIP gene, may have a protective effect against the development of Crohn's disease, based on a study of 469 Caucasian patients. The reported odds ratio is 0.77 (CI: 0.67-0.89, p=0.002).[PMID 18200509]

Note that rs1128535 is highly correlated (r2 > 0.8) to nonsynonymous SNPs in the nearby MST1R gene, rs2230590 and rs1062633, also known as Arg523Gln and Gly1335Arg, respectively. [PMID 18200509]


[PMID 19657358] Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility