Have questions? Visit https://www.reddit.com/r/SNPedia

rs1129844(A;A)

From SNPedia

Up to 10 year delay in onset of early-onset Alzheimer's (possibly)
Is agenotype
ofrs1129844
GeneCCL11
Chromosome17
Position34,285,875
mentionedby
Magnitude2.5
ReputeGood
Geno Mag Summary
(A;A) 2.5 Up to 10 year delay in onset of early-onset Alzheimer's (possibly)
(A;G) 2 Significant delay in onset of early-onset Alzheimer's; possibly a 2.5 year delay in onset of late-onset Alzheimer's

One publication reports that the (A;G) genotype of rs1129844 might delay by up to 10 years early-onset Alzheimer's disease caused by a mutation in the PSEN1 gene. It is not clear whether an Alzheimer's risk benefit might result from the (A;A) genotype. See additional discussion at rs1129844, and the citation to the study in which Supplementary Figure 5 shows a statistically nonsignificant, although positive, trend towards delayed onset of dementia in a UCSF patient cohort of late-onset Alzheimer's patients carrying the (A;A) rs1129844 genotype. This should be viewed cautiously until confirmed in larger Alzheimer's populations.