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rs1129844(A;G)

From SNPedia

Significant delay in onset of early-onset Alzheimer's; possibly a 2.5 year delay in onset of late-onset Alzheimer's
Is agenotype
ofrs1129844
GeneCCL11
Chromosome17
Position34,285,875
mentionedby
Magnitude2
ReputeGood
Geno Mag Summary
(A;A) 2.5 Up to 10 year delay in onset of early-onset Alzheimer's (possibly)
(A;G) 2 Significant delay in onset of early-onset Alzheimer's; possibly a 2.5 year delay in onset of late-onset Alzheimer's

One publication reports that the (A;G) genotype of rs1129844 might significantly delay the onset of early-onset Alzheimer's disease caused by a mutation in the PSEN1 gene. A followup study in late-onset Alzheimer patients found a 2.5 year later onset in those with AG versus GG genotype, but it was not statistically significant. This is an initial report and will need further replications. See additional discussion at rs1129844.