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rs1131532

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) normal
(C;T) normal
(T;T) 3-6x higher odds of worse outcomes in breast cancer patients
ReferenceGRCh38 38.1/141
Chromosome3
Position172506513
GeneTNFSF10
is asnp
is mentioned by
dbSNPrs1131532
ebirs1131532
HLIrs1131532
Exacrs1131532
Varsomers1131532
Maprs1131532
PheGenIrs1131532
hapmaprs1131532
1000 genomesrs1131532
hgdprs1131532
ensemblrs1131532
gopubmedrs1131532
geneviewrs1131532
scholarrs1131532
googlers1131532
pharmgkbrs1131532
gwascentralrs1131532
openSNPrs1131532
23andMers1131532
23andMe allrs1131532
SNP Nexus

SNPshotrs1131532
SNPdbers1131532
MSV3drs1131532
GWAS Ctlgrs1131532
GMAF0.3434
Max Magnitude
? (C;C) (C;T) (T;T) 28
rs1131532 is a SNP in the tumor necrosis factor superfamily member 10 TNFSF10 gene.

A study of 240 patients with early invasive ductal breast cancer followed for a median of 53 months concluded that rs1131532(T;T) individuals had lower odds of being disease-free or distant-disease free, and for overall survival (hazard ratio 3.304, 4.757, and 6.459; p = 0.002, 0.001, and 0.009, respectively).[PMID 19890662]


[PMID 18778477OA-icon.png] Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival.


[PMID 20031590OA-icon.png] The relation of genetic and environmental factors to systemic inflammatory biomarker concentrations.