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rs11362

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;G) 1
Make rs11362(A;A)
Make rs11362(G;G)
ReferenceGRCh38 38.1/141
Chromosome8
Position6877877
GeneDEFB1
is asnp
is mentioned by
dbSNPrs11362
ebirs11362
HLIrs11362
Exacrs11362
Varsomers11362
Maprs11362
PheGenIrs11362
hapmaprs11362
1000 genomesrs11362
hgdprs11362
ensemblrs11362
gopubmedrs11362
geneviewrs11362
scholarrs11362
googlers11362
pharmgkbrs11362
gwascentralrs11362
openSNPrs11362
23andMers11362
23andMe allrs11362
SNP Nexus

SNPshotrs11362
SNPdbers11362
MSV3drs11362
GWAS Ctlgrs11362
GMAF0.404
Max Magnitude1
? (A;A) (A;G) (G;G) 28
Heterozygotes for SNP rs11362, located in the DEFB1 gene, are reported to be at increased risk for colonic Crohn's disease - but not the ileal or ileocolonic forms of the disease - based on a study of 190 Caucasians. The odds ratio is 2.393 (CI: 1.18-4.87, p=0.02).[PMID 17943629]

[PMID 18938660] G-20A rs11362(A;G) 2.4x risk colonic and ileocolonic Crohn's disease but no association was detected for the ileal localization

Neighborrs1800972
Distance24


[PMID 19460328] SNP 668C (-44) alters a NF-kappaB1 putative binding site in non-coding strand of human beta-defensin 1 (DEFB1) and is associated with lepromatous leprosy


[PMID 20371866] The Antimicrobial Peptide DEFB1 is Associated with Caries

[PMID 20618470] Beta defensin-1 gene (DEFB1) polymorphisms are not associated with atopic dermatitis in children and adolescents from northeast Brazil (Recife, Pernambuco)


[PMID 16700921OA-icon.png] Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study.


[PMID 18396467OA-icon.png] Genetic variation and haplotype structures of innate immunity genes in eastern India.


[PMID 18991164] Potential role of human beta-defensin 1 in Helicobacter pylori-induced gastritis.


[PMID 19712472OA-icon.png] Association of a genetic polymorphism (-44 C/G SNP) in the human DEFB1 gene with expression and inducibility of multiple beta-defensins in gingival keratinocytes.


[PMID 22384213OA-icon.png] Genetic variability in beta-defensins is not associated with susceptibility to Staphylococcus aureus bacteremia.


[PMID 22809755] Immune defense single nucleotide polymorphisms and recruitment strategies associated with contact lens keratitis


[PMID 23204181] Impaired beta-defensin expression in human skin links DEFB1 promoter polymorphisms with persistent Staphylococcus aureus nasal carriage.


[PMID 25083086OA-icon.png] Relevance of α-defensins (HNP1-3) and defensin β-1 in diabetes


[PMID 25683590] Chronic tonsillitis is not associated with beta defensin 1 gene polymorphisms in Turkish population


[PMID 27846636] Caries and Innate Immunity: DEFB1 Gene Polymorphisms and Caries Susceptibility in Genetic Isolates from North-Eastern Italy.