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rs1137101

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common in clinvar
Make rs1137101(A;G)
Make rs1137101(G;G)
ReferenceGRCh38 38.1/141
Chromosome1
Position65592830
GeneLEPR
is asnp
is mentioned by
dbSNPrs1137101
ebirs1137101
HLIrs1137101
Exacrs1137101
Varsomers1137101
Maprs1137101
PheGenIrs1137101
hapmaprs1137101
1000 genomesrs1137101
hgdprs1137101
ensemblrs1137101
gopubmedrs1137101
geneviewrs1137101
scholarrs1137101
googlers1137101
pharmgkbrs1137101
gwascentralrs1137101
openSNPrs1137101
23andMers1137101
23andMe allrs1137101
SNP Nexus

SNPshotrs1137101
SNPdbers1137101
MSV3drs1137101
GWAS Ctlgrs1137101
GMAF0.4105
Max Magnitude0
? (A;A) (A;G) (G;G) 28
[PMID 19142102] obesity Q223R rs1137101 may be associated with obesity in women with a psychotic disorder treated with atypical antipsychotic drugs

[PMID 19337797] Gln223Arg polymorphism could be considered a disease susceptibility modulating factor both in ischemic heart disease or dilated cardiomyopathy patients.

OMIM601007
DescLEPTIN RECEPTOR POLYMORPHISM
Variant0003
Relatedalso


[PMID 19273568] Genetic variation in adipokine genes and risk of colorectal cancer


[PMID 19793853] Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO

[PMID 19818126OA-icon.png] Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study


[PMID 19921265] The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders


[PMID 20032477] Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults


[PMID 20183928] The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders


[PMID 20517895] Genetic variations of leptin and leptin receptor are associated with body composition changes in response to physical training

[PMID 20562674] Association between LEP and LEPR gene polymorphisms and dyslipidemia in patients using atypical antipsychotic medication

[PMID 20167575OA-icon.png] Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels


[PMID 20874424] Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis


[PMID 21512510] The Effect of Ponderal Index at Birth on the Relationships Between Common LEP and LEPR Polymorphisms and Adiposity in Adolescents


[PMID 21510767] Polymorphisms of the LEP-, LEPR and HTR2C gene: obesity and BMI change in patients using antipsychotic medication in a naturalistic setting


[PMID 21516303OA-icon.png] Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes


ClinVar
Risk rs1137101(G;G)
Alt rs1137101(G;G)
Reference rs1137101(A;A)
Significance Non-pathogenic
Disease LEPTIN RECEPTOR POLYMORPHISM
Variation info
Gene LEPR LEPROT
CLNDBN LEPTIN RECEPTOR POLYMORPHISM
Reversed 0
HGVS NC_000001.10:g.66058513A>G
CLNSRC OMIM Allelic Variant
CLNACC RCV000009047.3,



[PMID 18059035OA-icon.png] Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions.


[PMID 18212354OA-icon.png] Genes in glucose metabolism and association with spina bifida.


[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.


[PMID 18700015OA-icon.png] Linkage study of fibrinogen levels: the Strong Heart Family Study.


[PMID 19379518OA-icon.png] Development of a fingerprinting panel using medically relevant polymorphisms.


[PMID 19427969] LEPR p.Q223R Polymorphism influences plasma leptin levels and body mass index in Tunisian obese patients.


[PMID 20149225OA-icon.png] Leptin receptor (LEPR) SNP polymorphisms in HELLP syndrome patients determined by quantitative real-time PCR and melting curve analysis.


[PMID 20565774OA-icon.png] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.


[PMID 21233812] ADRB2 and LEPR gene polymorphisms: synergistic effects on the risk of obesity in Japanese.


[PMID 21390334OA-icon.png] Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study.


[PMID 21393862OA-icon.png] A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children.


[PMID 21947707OA-icon.png] Leptin and leptin receptor genes in relation to premenopausal breast cancer incidence and grade in Caucasian women.


GET Evidence
LEPR-Q223R
aa_change Gln223Arg
aa_change_short Q223R
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.486429
summary



[PMID 23278404] The impact of LEPR variants on risk of non-alcoholic fatty liver disease and its interaction with PNPLA3 variant


[PMID 23284729OA-icon.png] Aerobic Fitness Does Not Modify the Effect of FTO Variation on Body Composition Traits


[PMID 24146750OA-icon.png] Association of LEP G2548A and LEPR Q223R Polymorphisms with Cancer Susceptibility: Evidence from a Meta-Analysis


[PMID 24468228] Leptin Signaling and Hyperparathyroidism: Clinical and Genetic Associations


[PMID 22426215] Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain.


[PMID 22975643OA-icon.png] Leptin and leptin receptor genetic variants associate with habitual physical activity and the arm body composition response to resistance training.


[PMID 22983835] The association between polymorphisms in the leptin receptor gene and risk of breast cancer: a systematic review and pooled analysis.


[PMID 23009903] A polymorphism in the leptin receptor gene at position 223 is associated with growth hormone replacement therapy responsiveness in idiopathic short stature and growth hormone deficiency patients.


[PMID 23026206] The leptin receptor Gln223Arg polymorphism (rs1137101) mediates the postprandial lipaemic response, but only in males.


[PMID 25740917OA-icon.png] Association of LEPR and ANKK1 gene polymorphisms with weight gain in epilepsy patients receiving valproic acid


[PMID 25810718OA-icon.png] Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer


[PMID 25863476] The association between LEPR Q223R polymorphisms and breast cancer risk


[PMID 25923461OA-icon.png] IGF2, LEPR, POMC, PPARG, and PPARGC1 gene variants are associated with obesity-related risk phenotypes in Brazilian children and adolescents


[PMID 26192702] ADIPOQ-11377C>G Polymorphism Increases Risk of Adipokine Abnormalities and Child Obesity Regardless of Dietary Intake


[PMID 26588347] Melanocortin-4 Receptor Gene Variation Is Associated with Eating Behavior in Chilean Adults


[PMID 27459797] [Association of leptin receptor gene polymorphrism with metabolic syndrome in older Han adults from major cities in China].


[PMID 27457563] Association of rs1137101 polymorphism in LEPR and susceptibility to knee osteoarthritis in a Northwest Chinese Han population.