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rs113809142

From SNPedia

Alzheimer association
Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 3 somewhat higher risk for Alzheimers
(G;T) 2.8 ~2x higher risk for Alzheimer's disease
(T;T) 0 common/normal
ReferenceGRCh38.p2 38.2/144
Chromosome19
Position1056245
GeneABCA7
is asnp
is mentioned by
dbSNPrs113809142
ebirs113809142
HLIrs113809142
Exacrs113809142
Varsomers113809142
Maprs113809142
PheGenIrs113809142
hapmaprs113809142
1000 genomesrs113809142
hgdprs113809142
ensemblrs113809142
gopubmedrs113809142
geneviewrs113809142
scholarrs113809142
googlers113809142
pharmgkbrs113809142
gwascentralrs113809142
openSNPrs113809142
23andMers113809142
23andMe allrs113809142
SNP Nexus

SNPshotrs113809142
SNPdbers113809142
MSV3drs113809142
GWAS Ctlgrs113809142
Max Magnitude3
rs113809142, also known as c.4416+2T>G, is one of several loss-of-function ABCA7 mutations associated with Alzheimer's disease initially in Icelanders, and then replicated in other populations.[PMID 25807283]


Carriers of one rare rs113809142(G) allele are at roughly more than twice the risk for developing late-onset Alzheimer's disease compared to people having the most common genotype (T;T); the odds ratio is 4.47, p=3.4 × 10e−7.[PMID 25807283]