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rs1142345(G;G)

From SNPedia

possibly incapable of detoxifying
Is agenotype
ofrs1142345
GeneTPMT
Chromosome6
Position18,130,687
mentionedby
Magnitude3.5
ReputeBad
Geno Mag Summary
(A;A) 0 common in clinvar
(A;G) 3 TPMT*3C . impaired drug metabolism
(G;G) 3.5 possibly incapable of detoxifying

poor drug metabolism of some medications.

potentially encoding a variant incapable of detoxifying byproducts of certain antineoplastic and immunosuppressant drugs.

http://blog.23andme.com/health-traits/do-you-know-how-youll-respond-to-thiopurine-medications/