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rs1143627

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 common in clinvar
Make rs1143627(C;T)
Make rs1143627(T;T)
ReferenceGRCh38 38.1/141
Chromosome2
Position112836810
GeneIL1B
is asnp
is mentioned by
dbSNPrs1143627
ebirs1143627
HLIrs1143627
Exacrs1143627
Varsomers1143627
Maprs1143627
PheGenIrs1143627
hapmaprs1143627
1000 genomesrs1143627
hgdprs1143627
ensemblrs1143627
gopubmedrs1143627
geneviewrs1143627
scholarrs1143627
googlers1143627
pharmgkbrs1143627
gwascentralrs1143627
openSNPrs1143627
23andMers1143627
23andMe allrs1143627
SNP Nexus

SNPshotrs1143627
SNPdbers1143627
MSV3drs1143627
GWAS Ctlgrs1143627
GMAF0.4803
Max Magnitude0
? (C;C) (C;T) (T;T) 28
[PMID 16508980] associated with ankylosing spondylitis

[PMID 16961803] risk of Helicobacter pylori infection. Children carrying IL1A-889T had a lower risk of H. pylori positivity, compared to those carrying -889C, with each T allele associated with 43% risk reduction (OR = 0.57, 95% CI = 0.33-0.99, p-trend = .05)

upregulation of pro-inflammatory cytokines may protect against persistent H. pylori colonization.

Neighborrs16944
Distance480


[PMID 19280228] Interleukin-1 cluster gene polymorphisms in childhood IgA nephropathy

[PMID 19733643] Interleukin-1 region meta-analysis with osteoarthritis phenotypes

[PMID 19793334OA-icon.png] Association of the -31C/T functional polymorphism in the interleukin-1beta gene with the intractability of Graves' disease and the proportion of T helper type 17 cells


[PMID 20509889OA-icon.png] The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study


[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies


[PMID 21992747OA-icon.png] Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study


[PMID 21968104OA-icon.png] The association of genetic variants in interleukin-1 genes with cognition: findings from the cardiovascular health study

[PMID 16078996OA-icon.png] Association study of functional genetic variants of innate immunity related genes in celiac disease.

[PMID 17327408OA-icon.png] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

[PMID 17356794] Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract.

[PMID 17532232] Potential influence of IL1B haplotype and IL1A-IL1B-IL1RN extended haplotype on hand osteoarthritis risk.

[PMID 17592300OA-icon.png] Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype.

[PMID 17601350OA-icon.png] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 18464913OA-icon.png] A genome-wide association study identifies protein quantitative trait loci (pQTLs).

[PMID 18576312OA-icon.png] A broad analysis of IL1 polymorphism and rheumatoid arthritis.

[PMID 18633131OA-icon.png] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 18757527OA-icon.png] Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer.

[PMID 18842150OA-icon.png] Concurrent genotyping of Helicobacter pylori virulence genes and human cytokine SNP sites using whole genome amplified DNA derived from minute amounts of gastric biopsy specimen DNA.

[PMID 19016479] Tagging SNP association study of the IL-1beta gene (IL1B) and childhood-onset mood disorders.

[PMID 19043479OA-icon.png] Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.

[PMID 19066394OA-icon.png] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

[PMID 19092239OA-icon.png] Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation.

[PMID 19356949OA-icon.png] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

[PMID 19734419OA-icon.png] A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support.

[PMID 20012999OA-icon.png] The cancer anorexia/weight loss syndrome: exploring associations with single nucleotide polymorphisms (SNPs) of inflammatory cytokines in patients with non-small cell lung cancer.

[PMID 20437198] Three polymorphisms in interleukin-1beta gene and risk for breast cancer: a meta-analysis.

[PMID 20463618OA-icon.png] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 21111021] Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine.

[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.

[PMID 21240526] Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review.

[PMID 21385363OA-icon.png] Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.

[PMID 21448414OA-icon.png] Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease.

[PMID 21880580] Interaction between functional polymorphic variants in cytokine genes, established risk factors and susceptibility to basal cell carcinoma of skin.


[PMID 23592922OA-icon.png] Interleukin 1 beta promoter polymorphism is associated with keratoconus in a Japanese population


[PMID 24194923OA-icon.png] Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study


[PMID 23927441OA-icon.png] Genetic variants in IL1A and IL1B contribute to the susceptibility to 2009 pandemic H1N1 influenza A virus


[PMID 22858724] IL1B and VWF variants are associated with fibrinolytic early recanalization in patients with ischemic stroke.


[PMID 23029430OA-icon.png] Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.


[PMID 25222025OA-icon.png] Interleukin-1β-31C/T and -511T/C Polymorphisms Were Associated with Preeclampsia in Chinese Han Population


[PMID 25304949] Role of Genetic Polymorphisms in NFKB-Mediated Inflammatory Pathways in Response to Primary Chemoradiation Therapy for Rectal Cancer


[PMID 25374200] Genetic Polymorphism of Interleukin-1A (IL-1A), IL-1B, and IL-1 Receptor Antagonist (IL-1RN) and Prostate Cancer Risk


[PMID 25446437] Association of IL-1, IL-18, and IL-33 gene polymorphisms with late-onset Alzheimer׳s disease in a Hunan Han Chinese population


ClinVar
Risk rs1143627(T;T)
Alt rs1143627(T;T)
Reference rs1143627(C;C)
Significance Other
Disease Gastric cancer susceptibility after h. pylori infection
Variation info
Gene IL1B
CLNDBN Gastric cancer susceptibility after h. pylori infection
Reversed 1
HGVS NC_000002.11:g.113594387G>A
CLNSRC OMIM Allelic Variant
CLNACC RCV000015783.26,



[PMID 26141218] IL1B gene polymorphisms, age and the risk of non-small cell lung cancer in a Chinese population


[PMID 26200829] Association of Interleukin-1 Gene Single Nucleotide Polymorphisms with Keratoconus in Chinese Han Population


[PMID 26846412] Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study.


[PMID 27159547] Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α.


[PMID 27602547] Impact of IL1B gene polymorphisms and interleukin 1B levels on susceptibility to spontaneous preterm birth.