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rs11466345

From SNPedia

Orientationminus
Stabilizedminus
Make rs11466345(A;A)
Make rs11466345(A;G)
Make rs11466345(G;G)
ReferenceGRCh38 38.1/141
Chromosome19
Position41337556
GeneTGFB1
is asnp
is mentioned by
dbSNPrs11466345
ClinGenrs11466345
ebirs11466345
HLIrs11466345
Exacrs11466345
Varsomers11466345
Maprs11466345
PheGenIrs11466345
hapmaprs11466345
1000 genomesrs11466345
hgdprs11466345
ensemblrs11466345
gopubmedrs11466345
geneviewrs11466345
scholarrs11466345
googlers11466345
pharmgkbrs11466345
gwascentralrs11466345
openSNPrs11466345
23andMers11466345
23andMe allrs11466345
SNP Nexus

SNPshotrs11466345
SNPdbers11466345
MSV3drs11466345
GWAS Ctlgrs11466345
GMAF0.1529
Max Magnitude
? (A;A) (A;G) (G;G) 28
[PMID 18281501OA-icon.png] colorectal neoplasia

271 colorectal adenoma cases and 544 controls, and 535 colorectal adenocarcinoma cases and 656 controls.

  • rs6957(A) was associated with higher serum TGFbeta-1 [means (in ng/mL) and 95% confidence interval (95% CI) for AA or AG, 32.6 (30.6-34.7); GG, 29.0 (25.1-32.9); P(difference) = 0.05]
  • rs11466345(G;G) had a statistically significantly lower risk of adenocarcinoma [AG versus AA: odds ratio (OR), 0.9 (95% CI, 0.7-1.2); GG versus AA: OR, 0.4 (95% CI, 0.2-0.7); P(trend) = 0.01].
  • The haplotype carrying both variants was also statistically significantly associated with a reduced risk of adenocarcinoma (OR, 0.3; 95% CI, 0.1-0.8)


[PMID 23059779] A Study of Ethnic Differences in TGFβ1 Gene Polymorphisms and Effects on the Risk of Radiation Pneumonitis in Non-Small-Cell Lung Cancer