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rs1154155

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 2.5 2.5x increased risk for narcolepsy
(G;T) 1.5 1.94x increased risk for narcolepsy
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome14
Position22533736
GeneTRA
is asnp
is mentioned by
dbSNPrs1154155
ebirs1154155
HLIrs1154155
Exacrs1154155
Varsomers1154155
Maprs1154155
PheGenIrs1154155
hapmaprs1154155
1000 genomesrs1154155
hgdprs1154155
ensemblrs1154155
gopubmedrs1154155
geneviewrs1154155
scholarrs1154155
googlers1154155
pharmgkbrs1154155
gwascentralrs1154155
openSNPrs1154155
23andMers1154155
23andMe allrs1154155
SNP Nexus

SNPshotrs1154155
SNPdbers1154155
MSV3drs1154155
GWAS Ctlgrs1154155
GMAF0.2365
Max Magnitude2.5
? (G;G) (G;T) (T;T) 28
rs1154155 is a SNP in the TCRA T-cell receptor alpha gene. The minor allele is (G).

A study of 1,830 people with narcolepsy and cataplexy (a sudden loss of muscle tone that can cause people to collapse) compared to 2,164 healthy controls concluded that several SNPs in the TCRA gene were linked. The most significant association was with this SNP, rs1154155, with an average allelic odds ratio of 1.69 (genotypic odds ratios 1.94 and 2.55, p < 10e-21).[PMID 19412176OA-icon.png]

Note the following, though, as quoted from a Science News article: "Even with all of the known genetic risk factors, including the newly discovered version of the T cell receptor gene, a person has only a 1.5 percent chance of developing narcolepsy.... That suggests that, while narcolepsy is probably an autoimmune disorder, further genetic and environmental triggers and risk factors remain to be found."

HLA-DQB1*0602 and relevance to Narcolepsy related to vaccination

A study of 500+ Chinese patients with narcolepsy confirms that narcolepsy is strongly and dose dependently associated with rs1154155(G) in this population.[PMID 22177342OA-icon.png]


[PMID 19927159] Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype

GWAS snp
PMID [PMID 20711174]
Trait
Title Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy
Risk Allele G
P-val 5E-7
Odds Ratio 1.54 [1.30-1.95]
OMIM612851
Desc
Variant
Relatedalso


GET Evidence
rs1154155
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.125
summary



GWAS snp
PMID [PMID 24204295OA-icon.png]
Trait Narcolepsy
Title Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
Risk Allele G
P-val 5E-49
Odds Ratio 1.64 [1.53-1.75]


[PMID 24381371OA-icon.png] DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe