Have questions? Visit https://www.reddit.com/r/SNPedia

Rs11571833

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common in complete genomics
(T;T) 2
Make rs11571833(A;T)
ReferenceGRCh38 38.1/141
Chromosome13
Position32398489
GeneBRCA2
is asnp
is mentioned by
dbSNPrs11571833
ebirs11571833
Exacrs11571833
PheGenIrs11571833
nextbiors11571833
hapmaprs11571833
1000 genomesrs11571833
hgdprs11571833
ensemblrs11571833
gopubmedrs11571833
geneviewrs11571833
scholarrs11571833
googlers11571833
pharmgkbrs11571833
gwascentralrs11571833
openSNPrs11571833
23andMers11571833
23andMe allrs11571833
SNP Nexus

SNPshotrs11571833
SNPdbers11571833
MSV3drs11571833
GWAS Ctlgrs11571833
GMAF0.00551
Max Magnitude2
? (A;A) (A;T) (T;T) 28

This SNP, a variant in the BRCA2 gene, is 1 of 25 SNPs reported to represent independently minor, but cumulatively significant, increased risk for breast cancer. [PMID 17341484]

For details of all 25 SNPs in this group, along with the two methods used to calculate overall risk estimates for breast cancer, refer to the SNPedia breast cancer entry.

For this particular SNP, the risk (minor) allele is (T).

Neighborrs1801426
Distance258


ClinVar
Risk rs11571833(T;T)
Alt rs11571833(T;T)
Reference rs11571833(A;A)
Significance Non-pathogenic
Disease not provided BRCA1 and BRCA2 Hereditary Breast and Ovarian Cancer not specified Hereditary cancer-predisposing syndrome Familial cancer of breast
Variation info
Gene BRCA2
CLNDBN not provided BRCA1 and BRCA2 Hereditary Breast and Ovarian Cancer not specified Hereditary cancer-predisposing syndrome Familial cancer of breast
Reversed 0
HGVS NC_000013.11:g.32398489A>T
CLNSRC HGMD
CLNACC RCV000034474.3, RCV000045926.3, RCV000120374.2, RCV000128910.2, RCV000157753.1,



[PMID 18974781OA-icon.png] Cataloging coding sequence variations in human genome databases.

GWAS snp
PMID [PMID 23535733OA-icon.png]
Trait Breast cancer
Title Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
Risk Allele T
P-val 6E-6
Odds Ratio 1.52 [1.31-1.77]
GWAS snp
PMID [PMID 23535729OA-icon.png]
Trait Breast cancer
Title Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Risk Allele T
P-val 5E-8
Odds Ratio 1.26 [1.14-1.39]
GWAS snp
PMID [PMID 24880342OA-icon.png]
Trait Lung cancer
Title Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.
Risk Allele T
P-val 2E-19
Odds Ratio 1.83 [1.61-2.09]


[PMID 25838448] A Rare Truncating BRCA2 Variant and Genetic Susceptibility to Upper Aerodigestive Tract Cancer