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rs11615

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(T;T) 0 common in clinvar
Make rs11615(C;C)
Make rs11615(C;T)
ReferenceGRCh38 38.1/141
Chromosome19
Position45420395
GeneERCC1
is asnp
is mentioned by
dbSNPrs11615
ebirs11615
HLIrs11615
Exacrs11615
Varsomers11615
Maprs11615
PheGenIrs11615
hapmaprs11615
1000 genomesrs11615
hgdprs11615
ensemblrs11615
gopubmedrs11615
geneviewrs11615
scholarrs11615
googlers11615
pharmgkbrs11615
gwascentralrs11615
openSNPrs11615
23andMers11615
23andMe allrs11615
SNP Nexus

SNPshotrs11615
SNPdbers11615
MSV3drs11615
GWAS Ctlgrs11615
GMAF0.3627
Max Magnitude0
? (C;C) (C;T) (T;T) 28



[PMID 21739480] Potentially functional polymorphisms in DNA repair genes and non-small-cell lung cancer survival: A pathway-based analysis


[PMID 21826087OA-icon.png] Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy

[PMID 15734977] Gene-smoking interaction associations for the ERCC1 polymorphisms in the risk of lung cancer.

[PMID 17299578OA-icon.png] Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: a meta-analysis.

[PMID 18332046] A distinct ERCC1 haplotype is associated with mRNA expression levels in prostate cancer patients.

[PMID 18544627OA-icon.png] Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk.

[PMID 18635523OA-icon.png] Genotypes and haplotypes of ERCC1 and ERCC2/XPD genes predict levels of benzo[a]pyrene diol epoxide-induced DNA adducts in cultured primary lymphocytes from healthy individuals: a genotype-phenotype correlation analysis.

[PMID 18990748OA-icon.png] International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.

[PMID 19361884] Effects of excision repair cross-complementation group 1 (ERCC1) single nucleotide polymorphisms on the prognosis of non-small cell lung cancer patients.

[PMID 19536092OA-icon.png] Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.

[PMID 20003391OA-icon.png] ERCC2, ERCC1 polymorphisms and haplotypes, cooking oil fume and lung adenocarcinoma risk in Chinese non-smoking females.

[PMID 20003463OA-icon.png] Association between polymorphisms in DNA repair genes and survival of non-smoking female patients with lung adenocarcinoma.

[PMID 21278243OA-icon.png] ERCC1 and ERCC2 polymorphisms predict clinical outcomes of oxaliplatin-based chemotherapies in gastric and colorectal cancer: a systemic review and meta-analysis.

[PMID 21315089OA-icon.png] The ERCC1 N118N polymorphism does not change cellular ERCC1 protein expression or platinum sensitivity.

[PMID 21364592OA-icon.png] CYP2A6 and ERCC1 polymorphisms correlate with efficacy of S-1 plus cisplatin in metastatic gastric cancer patients.

[PMID 21553053] The determination of relationship between "excision repair cross-complementing group 1" (ERCC1) gene T19007C and C8092A single nucleotide polymorphisms and clinicopathological parameters in non-small cell lung cancer.

[PMID 21601580] HapMap-based study of a region encompassing ERCC1 and ERCC2 related to lung cancer susceptibility in a Chinese population.

[PMID 21956434] Neoadjuvant radiochemotherapy in adenocarcinoma of the esophagus: ERCC1 gene polymorphisms for prediction of response and prognosis.

[PMID 22002622] Nucleotide excision repair gene ERCC1 polymorphisms contribute to cancer susceptibility: a meta-analysis.

[PMID 22201261] ERCC1 polymorphisms and risk of adult glioma in a Chinese population: a hospital-based case-control study.

[PMID 22335888] A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population.


[PMID 23166636OA-icon.png] Polymorphisms in ERCC1 and XPF Genes and Risk of Gastric Cancer in an Eastern Chinese Population


[PMID 23147699] Association of genetic polymorphisms in ERCC1 and ERCC2/XPD with risk of chronic benzene poisoning in a Chinese occupational population


[PMID 23680703] A genetic variant in ERCC2 is associated with gastric cancer prognosis in a Chinese population


[PMID 23684781OA-icon.png] Phase II Study of Satraplatin and Prednisone in Patients With Metastatic Castration-Resistant Prostate Cancer: A Pharmacogenetic Assessment of Outcome and Toxicity


[PMID 23909490OA-icon.png] Polymorphisms in the ERCC1 and XPF Genes and Risk of Breast Cancer in a Chinese Population


[PMID 23936089OA-icon.png] Polymorphisms in DNA-Repair Genes in a Cohort of Prostate Cancer Patients from Different Areas in Spain: Heterogeneity between Populations as a Confounding Factor in Association Studies


[PMID 23962907] ERCC1 C8092A (rs3212986) polymorphism as a predictive marker in esophageal cancer patients treated with cisplatin/5-FU-based neoadjuvant therapy


[PMID 24103542] High-throughput genotyping system as a robust and useful tool in oncology: Experience from a single institution


[PMID 24325908] Analysis of dna repair gene polymorphisms in glioblastoma


[PMID 24499239] Predicting the outcome of platinum-based chemotherapies in epithelial ovarian cancer using the 8092C/A polymorphism of ERCC1: a meta-analysis


[PMID 22821389] Polymorphisms of ERCC1 genotype associated with response to imatinib therapy in chronic phase chronic myeloid leukemia.


[PMID 23175176OA-icon.png] Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype.


[PMID 23180017] PPP1R13L variant associated with prognosis for patients with rectal cancer.


[PMID 23203453] Excision repair of BPDE-adducts in human lymphocytes: diminished capacity associated with ERCC1 C8092A (rs3212986) polymorphism.


[PMID 24859833] Polymorphisms in ERCC1 gene could predict clinical outcome of platinum-based chemotherapy for non-small cell lung cancer patients


[PMID 24861646] Association of single nucleotide polymorphisms of ERCC1 and XPF with colorectal cancer risk and interaction with tobacco use


[PMID 24939416OA-icon.png] CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients


[PMID 25789018OA-icon.png] Analysis of ERCC1 and ERCC2 gene variants in osteosarcoma, colorectal and breast cancer


[PMID 25834456OA-icon.png] Association between the ERCC1 rs11615 polymorphism and clinical outcomes of oxaliplatin-based chemotherapies in gastrointestinal cancer: a meta-analysis


[PMID 26022132] Association of ERCC1 polymorphisms (rs3212986 and rs11615) with the risk of head and neck carcinomas based on case-control studies


[PMID 26254278OA-icon.png] Impact of VEGF, VEGFR, PDGFR, HIF and ERCC1 gene polymorphisms on thymic malignancies outcome after thymectomy


[PMID 26253951] Use a survival model to correlate single-nucleotide polymorphisms of DNA repair genes with radiation dose-response in patients with non-small cell lung cancer


[PMID 26264164] A Comprehensive Analysis of Influence ERCC Polymorphisms Confer on the Development of Brain Tumors


[PMID 26339355OA-icon.png] Genetic polymorphisms in nucleotide excision repair pathway influences response to chemotherapy and overall survival in osteosarcoma


[PMID 26400354] Investigation of ERCC1 and ERCC2 gene polymorphisms and response to chemotherapy and overall survival in osteosarcoma


[PMID 26436406] Genetic variability of genes involved in DNA repair influence treatment outcome in osteosarcoma


[PMID 26475344OA-icon.png] CYP39A1 polymorphism is associated with toxicity during intensive induction chemotherapy in patients with advanced head and neck cancer


[PMID 27668351] Study of association between pre-senile cataracts and rs11615 of ERCC1, rs13181 of ERCC2, and rs25487 of XRCC1 polymorphisms in a Spanish population.


ClinVar
Risk rs11615(C;C)
Alt rs11615(C;C)
Reference rs11615(T;T)
Significance Drug-response
Disease platinum response - Efficacy carboplatin response - Efficacy Platinum compounds response - Efficacy cisplatin response - Efficacy oxaliplatin response - Efficacy
Variation info
Gene ERCC1
CLNDBN platinum response - Efficacy, Toxicity/ADR carboplatin response - Efficacy, Toxicity/ADR Platinum compounds response - Efficacy, Toxicity/ADR cisplatin response - Efficacy, Toxicity/ADR oxaliplatin response - Efficacy, Toxicity/ADR
Reversed 1
HGVS NC_000019.9:g.45923653A>G
CLNSRC PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000211176.1, RCV000211179.1, RCV000211295.1, RCV000211304.1, RCV000211427.1,



[PMID 27741011] Molecular Markers for the Prediction of Minor Response to Neoadjuvant Chemoradiation in Esophageal Cancer: Results of the Prospective Cologne Esophageal Response Prediction (CERP) Study.