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rs11649622

From SNPedia

Orientationplus
Stabilizedplus
Make rs11649622(A;A)
Make rs11649622(A;G)
Make rs11649622(G;G)
ReferenceGRCh38 38.1/142
Chromosome16
Position83571660
GeneCDH13
is asnp
is mentioned by
dbSNPrs11649622
ebirs11649622
HLIrs11649622
Exacrs11649622
Varsomers11649622
Maprs11649622
PheGenIrs11649622
hapmaprs11649622
1000 genomesrs11649622
hgdprs11649622
ensemblrs11649622
gopubmedrs11649622
geneviewrs11649622
scholarrs11649622
googlers11649622
pharmgkbrs11649622
gwascentralrs11649622
openSNPrs11649622
23andMers11649622
23andMe allrs11649622
SNP Nexus

SNPshotrs11649622
SNPdbers11649622
MSV3drs11649622
GWAS Ctlgrs11649622
Max Magnitude
? (A;A) (A;G) (G;G) 28
rs11649622 is a SNP within an intron of the cadherin 13 CDH13 gene on chromosome 16.

In a study of a cohort of Finnish prisoners, the rs11649622(A) allele showed the strongest statistical association with violent crime (specifically, homicides). This SNP was also part of a haplotype (including rs12919501, rs4075942, and rs7190768) linked to violent crime. The authors point out state that more than 20 studies have found associations between CDH13 - although not this specific SNP - and attention deficit/hyperactivity disorder (ADHD), autism, schizophrenia, substance abuse or bipolar disorder. They also point out that given a population frequency of over 15% for this allele, compared to orders of magnitude lower frequencies of violent crime, the specificity and sensitivity of using this SNP to would be far "too low for any screening purposes, either for primary or secondary prevention of violent offending".[PMID 25349169]

In the same study, the low-activity form of the MAOA gene was also associated with extreme violent crime. In SNPedia, the proxy SNP for this variant is rs909525. The odds ratio associated with extreme violent crime for combined homozygosity for low-activity MAOA (i.e. rs909525(G;G)) and rs11649622(A;A) was 13.45 (95% CI 3.86–46.94; no p value stated).[PMID 25349169]