Have questions? Visit https://www.reddit.com/r/SNPedia

rs11649743

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2.5 Lower prostate cancer risk?
Make rs11649743(A;G)
Make rs11649743(G;G)
ReferenceGRCh38 38.1/141
Chromosome17
Position37714971
GeneHNF1B
is asnp
is mentioned by
dbSNPrs11649743
ebirs11649743
HLIrs11649743
Exacrs11649743
Varsomers11649743
Maprs11649743
PheGenIrs11649743
hapmaprs11649743
1000 genomesrs11649743
hgdprs11649743
ensemblrs11649743
gopubmedrs11649743
geneviewrs11649743
scholarrs11649743
googlers11649743
pharmgkbrs11649743
gwascentralrs11649743
openSNPrs11649743
23andMers11649743
23andMe allrs11649743
SNP Nexus

SNPshotrs11649743
SNPdbers11649743
MSV3drs11649743
GWAS Ctlgrs11649743
GMAF0.2025
Max Magnitude2.5
? (A;A) (A;G) (G;G) 28
[PMID 19998368OA-icon.png] rs11649743 identified as one of three HNF1B gene SNPs associated with decreased risk for prostate cancer in two large prospective studies

[PMID 18758462OA-icon.png] prostate cancer rs4430796 and rs11649743 in multiple populations, with P = 1.7 x 10(-9)

OMIM611955
DescPROSTATE CANCER, HEREDITARY, 11; HPC11
Variant
Relatedalso
[PMID 21576123OA-icon.png] Large-scale fine mapping of the HNF1B locus and prostate cancer risk


[PMID 19117981OA-icon.png] Sequence variants at 22q13 are associated with prostate cancer risk.


[PMID 19168595OA-icon.png] Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population.


[PMID 19318432OA-icon.png] Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.


[PMID 19434657OA-icon.png] Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.


[PMID 19549807OA-icon.png] Prostate cancer risk associated loci in African Americans.


[PMID 20039378OA-icon.png] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.


[PMID 20569440OA-icon.png] Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer.


[PMID 21390317OA-icon.png] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.


GET Evidence
rs11649743
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.09375
summary



[PMID 23405784] [Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases]