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rs11650354

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common/normal
(C;T) 1.1 possible risk for allergic asthma
(T;T) 2 8x risk for allergic asthma
ReferenceGRCh38 38.1/141
Chromosome17
Position47744726
GeneTBX21
is asnp
is mentioned by
dbSNPrs11650354
ebirs11650354
HLIrs11650354
Exacrs11650354
Varsomers11650354
Maprs11650354
PheGenIrs11650354
hapmaprs11650354
1000 genomesrs11650354
hgdprs11650354
ensemblrs11650354
gopubmedrs11650354
geneviewrs11650354
scholarrs11650354
googlers11650354
pharmgkbrs11650354
gwascentralrs11650354
openSNPrs11650354
23andMers11650354
23andMe allrs11650354
SNP Nexus

SNPshotrs11650354
SNPdbers11650354
MSV3drs11650354
GWAS Ctlgrs11650354
GMAF0.1244
Max Magnitude2
? (C;C) (C;T) (T;T) 28
A large study of Caucasian children has identified this SNP in the TBX21 gene (and one other, rs16947078) as defining a haplotype associated with increased risk for allergic asthma. [PMID 17949803]

The odds ratio associated with rs11650354(T;T) homozygotes compared to rs11650354(C;C) homozygotes for allergic asthma is reported to be 8.13 (CI: 2.5-26.9). Heterozygotes may be at slightly higher risk. [PMID 17949803]


[PMID 19950257OA-icon.png] Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: Evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines

[PMID 18504423OA-icon.png] Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response.