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rs11672691

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;G) 2 1.18x increased risk for PCSM in patients with prostate cancer
(G;G) 2.5 1.39x increased risk for PCSM in patients with prostate cancer


Make rs11672691(A;A)
ReferenceGRCh38 38.1/141
Chromosome19
Position41479679
GeneSLC26A6
is asnp
is mentioned by
dbSNPrs11672691
ebirs11672691
HLIrs11672691
Exacrs11672691
Varsomers11672691
Maprs11672691
PheGenIrs11672691
hapmaprs11672691
1000 genomesrs11672691
hgdprs11672691
ensemblrs11672691
gopubmedrs11672691
geneviewrs11672691
scholarrs11672691
googlers11672691
pharmgkbrs11672691
gwascentralrs11672691
openSNPrs11672691
23andMers11672691
23andMe allrs11672691
SNP Nexus

SNPshotrs11672691
SNPdbers11672691
MSV3drs11672691
GWAS Ctlgrs11672691
GMAF0.449
Max Magnitude2.5
rs11672691 is a SNP on chromosome 19 located between the ATP5SL and CEACAM21 genes and within LOC100505495, a possible noncoding RNA.[PMID 23065704OA-icon.png]

A large study of over 10,000 patients with prostate cancer concluded that each rs11672691(G) allele was associated with an increased risk (by 1.18x) of prostate cancer specific mortality (PCSM), i.e. death from the cancer.[PMID 24411283OA-icon.png]

A meta-analysis of 4 studies totaling ~6000 patients with prostate cancer and follow up in 49,000 samples concluded that rs11672691 was associated with increased susceptibility (odds ratio 1.12, CI:1.03–1.21, p = 1.4 x 10e-8) but also with aggressive prostate cancer and therefore a poorer prognosis.[PMID 23065704OA-icon.png]

? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 23065704OA-icon.png]
Trait Prostate cancer
Title A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.
Risk Allele G
P-val 1E-8
Odds Ratio 1.11 [1.02-1.20]