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rs1169300

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 ~2x increased lung cancer risk
(A;G) 1.5 ~1.5x increased lung cancer risk
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome12
Position120993422
GeneHNF1A
is asnp
is mentioned by
dbSNPrs1169300
ebirs1169300
HLIrs1169300
Exacrs1169300
Varsomers1169300
Maprs1169300
PheGenIrs1169300
hapmaprs1169300
1000 genomesrs1169300
hgdprs1169300
ensemblrs1169300
gopubmedrs1169300
geneviewrs1169300
scholarrs1169300
googlers1169300
pharmgkbrs1169300
gwascentralrs1169300
openSNPrs1169300
23andMers1169300
23andMe allrs1169300
SNP Nexus

SNPshotrs1169300
SNPdbers1169300
MSV3drs1169300
GWAS Ctlgrs1169300
GMAF0.3315
Max Magnitude2
? (A;A) (A;G) (G;G) 28
rs1169300 is a SNP that was originally associated with C-reactive protein levels, and given other findings that suggest C-reactive protein levels may be predictive of cancer risk, was thought to be linked to cancer risk.

A large study pooling data from 3 Finnish studies totaling over 18,000 individuals concluded that while this SNP is not likely to be causative (relative to cancer), it and one other CRP SNP (rs2464196) are associated with increased risk for lung cancer. The odds ratio for minor alleles of either SNP was about 1.5x and 2x for heterozygotes and homozygotes, respectively. One other CRP SNP (rs1892534) was associated with increased overall cancer risk. CRP SNPs were not associated with colorectal, prostate or breast cancer risk.[PMID 20727736]


[PMID 18439548OA-icon.png] Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.


[PMID 18599530OA-icon.png] Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients.


[PMID 19060910OA-icon.png] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.