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rs1170191

From SNPedia

Orientationminus
Stabilizedminus
Make rs1170191(C;C)
Make rs1170191(C;T)
Make rs1170191(T;T)
ReferenceGRCh38 38.1/141
Chromosome13
Position42101357
GeneDGKH
is asnp
is mentioned by
dbSNPrs1170191
ebirs1170191
HLIrs1170191
Exacrs1170191
Varsomers1170191
Maprs1170191
PheGenIrs1170191
hapmaprs1170191
1000 genomesrs1170191
hgdprs1170191
ensemblrs1170191
gopubmedrs1170191
geneviewrs1170191
scholarrs1170191
googlers1170191
pharmgkbrs1170191
gwascentralrs1170191
openSNPrs1170191
23andMers1170191
23andMe allrs1170191
SNP Nexus

SNPshotrs1170191
SNPdbers1170191
MSV3drs1170191
GWAS Ctlgrs1170191
GMAF0.2681
Max Magnitude
? (C;C) (C;T) (T;T) 28
In a survey that scanned 80 genes, no SNPs with a large effect were found to be associated with bipolar disorder. However, the SNP with the largest association was rs1170191, in first intron of the diacylglycerol kinase eta DGKH gene. The odds ratio for the risk allele of this SNP is 1.59 (p = 1.5x10e-8, experiment-wide p<0.01).[PMID 17486107OA-icon.png]


[PMID 18421293OA-icon.png] Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement.


[PMID 19308021OA-icon.png] Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.


[PMID 19818381] Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorphisms in 199 Sardinian bipolar patients.


[PMID 22048461OA-icon.png] Effect of variation in diacylglycerol kinase eta (DGKH) gene on brain function in a cohort at familial risk of bipolar disorder.