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rs11708067

From SNPedia

Orientationplus
Stabilizedplus
Make rs11708067(A;A)
Make rs11708067(A;G)
Make rs11708067(G;G)
ReferenceGRCh38 38.1/141
Chromosome3
Position123346931
GeneADCY5
is asnp
is mentioned by
dbSNPrs11708067
ebirs11708067
HLIrs11708067
Exacrs11708067
Varsomers11708067
Maprs11708067
PheGenIrs11708067
hapmaprs11708067
1000 genomesrs11708067
hgdprs11708067
ensemblrs11708067
gopubmedrs11708067
geneviewrs11708067
scholarrs11708067
googlers11708067
pharmgkbrs11708067
gwascentralrs11708067
openSNPrs11708067
23andMers11708067
23andMe allrs11708067
SNP Nexus

SNPshotrs11708067
SNPdbers11708067
MSV3drs11708067
GWAS Ctlgrs11708067
GMAF0.1364
Max Magnitude
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 20081858OA-icon.png]
Trait Fasting glucose-related traits
Title New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Risk Allele A
P-val 3E-12
Odds Ratio None None


[PMID 20490451] Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight


OMIM613460
Desc
Variant
Relatedalso
[PMID 21887289OA-icon.png] Glucose-Raising Genetic Variants in MADD and ADCY5 Impair Conversion of Proinsulin to Insulin


[PMID 21949744OA-icon.png] Effects of 16 Genetic Variants on Fasting Glucose and Type 2 Diabetes in South Asians: ADCY5 and GLIS3 Variants May Predispose to Type 2 Diabetes

[PMID 20081857OA-icon.png] Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.

GWAS snp
PMID [PMID 22693455OA-icon.png]
Trait
Title Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
Risk Allele A
P-val 6E-8
Odds Ratio 1.2500 None
GWAS snp
PMID [PMID 22581228OA-icon.png]
Trait
Title A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
Risk Allele
P-val 3E-10
Odds Ratio None None


GET Evidence
rs11708067
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.131148
summary



[PMID 22698489OA-icon.png] Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study.


[PMID 23462794OA-icon.png] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.


[PMID 25793868OA-icon.png] ADCY5 Gene Expression in Adipose Tissue Is Related to Obesity in Men and Mice