Have questions? Visit https://www.reddit.com/r/SNPedia

rs11718863

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;T) 1.43x increased osteoarthritis risk
(T;T) 1.43x increased osteoarthritis risk
ReferenceGRCh38 38.1/141
Chromosome3
Position15175196
GeneCOL6A4P1
is asnp
is mentioned by
dbSNPrs11718863
ebirs11718863
HLIrs11718863
Exacrs11718863
Varsomers11718863
Maprs11718863
PheGenIrs11718863
hapmaprs11718863
1000 genomesrs11718863
hgdprs11718863
ensemblrs11718863
gopubmedrs11718863
geneviewrs11718863
scholarrs11718863
googlers11718863
pharmgkbrs11718863
gwascentralrs11718863
openSNPrs11718863
23andMers11718863
23andMe allrs11718863
SNP Nexus

SNPshotrs11718863
SNPdbers11718863
MSV3drs11718863
GWAS Ctlgrs11718863
GMAF0.2305
Max Magnitude0
? (A;A) (A;T) (T;T) 28
rs11718863 is one of several SNPs in the DVWA gene found to be associated with osteoarthritis based on a study of several Japanese patient populations. The allelic odds ratio is 1.43 (CI: 1.26-1.63, p = 5.2 x 10e-8) for the minor allele, which is the (T) allele (in dbSNP orientation). [PMID 18622395]
OMIM612401
DescOSTEOARTHRITIS SUSCEPTIBILITY 6; OS6
Variant
Relatedalso


[PMID 20238217] Lack of evidence for association between DVWA gene polymorphisms and developmental dysplasia of the hip in Chinese Han population

[PMID 19054821] Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations.

[PMID 19181678] Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations.


[PMID 26550167OA-icon.png] The association between DVWA polymorphisms and osteoarthritis susceptibility: a genetic meta-analysis