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rs1183910

From SNPedia

Orientationminus
Stabilizedminus
Make rs1183910(C;C)
Make rs1183910(C;T)
Make rs1183910(T;T)
ReferenceGRCh38 38.1/141
Chromosome12
Position120983004
GeneHNF1A
is asnp
is mentioned by
dbSNPrs1183910
ebirs1183910
HLIrs1183910
Exacrs1183910
Varsomers1183910
Maprs1183910
PheGenIrs1183910
hapmaprs1183910
1000 genomesrs1183910
hgdprs1183910
ensemblrs1183910
gopubmedrs1183910
geneviewrs1183910
scholarrs1183910
googlers1183910
pharmgkbrs1183910
gwascentralrs1183910
openSNPrs1183910
23andMers1183910
23andMe allrs1183910
SNP Nexus

SNPshotrs1183910
SNPdbers1183910
MSV3drs1183910
GWAS Ctlgrs1183910
GMAF0.3039
Max Magnitude
? (C;C) (C;T) (T;T) 28

23andMe blog each rs1183910(T) lowered CRP by 13.8% also associated with higher total cholesterol, LDL choesterol and HDL cholesterol.

[PMID 19567438OA-icon.png] Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease

GWAS snp
PMID [PMID 21300955OA-icon.png]
Trait
Title Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels
Risk Allele G
P-val 2E-124
Odds Ratio 0.1490 [0.14-0.16] unit increase


[PMID 18439552OA-icon.png] Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.


GET Evidence
rs1183910
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.25
summary



GWAS snp
PMID [PMID 23844046OA-icon.png]
Trait C-reactive protein
Title Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?
Risk Allele G
P-val 4E-12
Odds Ratio .05 [NR] unit increase