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rs11889341

From SNPedia

Orientationplus
Stabilizedplus
Make rs11889341(C;C)
Make rs11889341(C;T)
Make rs11889341(T;T)
ReferenceGRCh38 38.1/141
Chromosome2
Position191079016
GeneSTAT4
is asnp
is mentioned by
dbSNPrs11889341
ebirs11889341
HLIrs11889341
Exacrs11889341
Varsomers11889341
Maprs11889341
PheGenIrs11889341
hapmaprs11889341
1000 genomesrs11889341
hgdprs11889341
ensemblrs11889341
gopubmedrs11889341
geneviewrs11889341
scholarrs11889341
googlers11889341
pharmgkbrs11889341
gwascentralrs11889341
openSNPrs11889341
23andMers11889341
23andMe allrs11889341
SNP Nexus

SNPshotrs11889341
SNPdbers11889341
MSV3drs11889341
GWAS Ctlgrs11889341
GMAF0.2456
Max Magnitude
? (C;C) (C;T) (T;T) 28
OMIM180300
DescRHEUMATOID ARTHRITIS; RA
Variant
Relatedalso
OMIM600558
DescSIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4; STAT4
Variant
Relatedalso


[PMID 19737838] A haplotype in STAT4 gene associated with rheumatoid arthritis in Caucasians is not associated in the Han Chinese population, but with the presence of rheumatoid factor

[PMID 19950257OA-icon.png] Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: Evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines


[PMID 20176035] Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease


[PMID 21683716] Signal transducer and activator of transcription 4 gene polymorphisms associated with rheumatoid arthritis in Northwestern Chinese Han population


[PMID 22483685] Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population

[PMID 17932559OA-icon.png] Association of STAT4 with rheumatoid arthritis in the Korean population.

[PMID 18434327OA-icon.png] Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.

[PMID 18516230OA-icon.png] Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.

[PMID 18579578OA-icon.png] A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.

[PMID 18803832OA-icon.png] Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region.

[PMID 19674979OA-icon.png] Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.

[PMID 20454450OA-icon.png] Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.

[PMID 22569826] Abnormal Genetic and Epigenetic Changes in Signal Transducer and Activator of Transcription 4 in the Pathogenesis of Inflammatory Bowel Diseases.


[PMID 24059108] [Signal transducer and activator of transcription 4 gene polymorphisms associated with dilated cardiomyopathy in Chinese Han population]


[PMID 24386384OA-icon.png] Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis

GWAS snp
PMID [PMID 24390342OA-icon.png]
Trait Rheumatoid arthritis
Title Genetics of rheumatoid arthritis contributes to biology and drug discovery.
Risk Allele T
P-val 4E-19
Odds Ratio 1.13 [1.10-1.17]