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rs11978267

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal/common
(G;G) 2 possible increased risk for infant acute myeloid leukemia (AML)
Make rs11978267(A;G)
ReferenceGRCh38 38.1/141
Chromosome7
Position50398606
GeneIKZF1
is asnp
is mentioned by
dbSNPrs11978267
ebirs11978267
HLIrs11978267
Exacrs11978267
Varsomers11978267
Maprs11978267
PheGenIrs11978267
hapmaprs11978267
1000 genomesrs11978267
hgdprs11978267
ensemblrs11978267
gopubmedrs11978267
geneviewrs11978267
scholarrs11978267
googlers11978267
pharmgkbrs11978267
gwascentralrs11978267
openSNPrs11978267
23andMers11978267
23andMe allrs11978267
SNP Nexus

SNPshotrs11978267
SNPdbers11978267
MSV3drs11978267
GWAS Ctlgrs11978267
GMAF0.2282
Max Magnitude2
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 19684603OA-icon.png]
Trait Acute lymphoblastic leukemia (childhood)
Title Germline genomic variants associated with childhood acute lymphoblastic leukemia
Risk Allele G
P-val 8E-11
Odds Ratio 1.69 [1.40-1.90]
OMIM613067
Desc
Variant
Relatedalso
[PMID 22422485OA-icon.png] Genetic variants modify susceptibility to leukemia in infants: A Children's Oncology Group report


GET Evidence
rs11978267
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.21875
summary



[PMID 23692655OA-icon.png] ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group


[PMID 24564228OA-icon.png] ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia