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rs12007229

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 Increased risk for incident vascular dementia
Make rs12007229(A;A)
Make rs12007229(A;C)
ReferenceGRCh38 38.1/141
ChromosomeX
Position67528513
is asnp
is mentioned by
dbSNPrs12007229
ebirs12007229
HLIrs12007229
Exacrs12007229
Varsomers12007229
Maprs12007229
PheGenIrs12007229
hapmaprs12007229
1000 genomesrs12007229
hgdprs12007229
ensemblrs12007229
gopubmedrs12007229
geneviewrs12007229
scholarrs12007229
googlers12007229
pharmgkbrs12007229
gwascentralrs12007229
openSNPrs12007229
23andMers12007229
23andMe allrs12007229
SNP Nexus

SNPshotrs12007229
SNPdbers12007229
MSV3drs12007229
GWAS Ctlgrs12007229
GMAF0.101
Max Magnitude0
? (A;A) (A;C) (C;C) 28
rs12007229 is located on the X chromosome near the androgen receptor gene.

In a genome-wide association study of 5700 dementia-free individuals, 67 patients developed incident vascular dementia over a mean follow-up time of 9.3±3.2 years. The rs12007229(A) allele was associated with this development (odds ratio 3.7, CI: 2.3-5.8, p = 1.3×10e-8). The association was further confirmed in 2 independent populations (probability value of combined replication samples=0.024).[PMID 22116812]


[PMID 15570555OA-icon.png] Systematic evaluation of genetic variation at the androgen receptor locus and risk of prostate cancer in a multiethnic cohort study.


[PMID 27103528] Association of genetic risk factors with cognitive decline: the PATH through life project.