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Using an innovative GWAS technique, SNPs influencing the age of onset for Alzheimer's disease in carriers of the p.Glu282Ala mutation was determined.
rs 12129547 (closest gene GREM2) combined p value=1.7x10-13.
This result has not been replicated, though the p value
determined in this initial study was highly significant.
Further, this result might be limited to the PSEN1 p.Glu282Ala Columbian kindred in this study.
The magnitude of the change in age of onset of AD was not presented in the article.