Rs12255372
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs12255372 |
| hapmap | rs12255372 |
| hgdp | rs12255372 |
| ensembl | rs12255372 |
| gopubmed | rs12255372 |
| scholar | rs12255372 |
| rs12255372 | |
| pharmgkb | rs12255372 |
| hgvbaseg2p | rs12255372 |
| medrefsnp | rs12255372 |
| 23andMe | rs12255372 |
| SNP Nexus |
| Gene | TCF7L2 |
| Chromosome | 10 |
| Orientation | plus |
| Position | 114798891 |
| Genotype | Effect |
|---|---|
| rs12255372(G;G) | |
| rs12255372(G;T) | 1.3x increased type-2 diabetes risk |
| rs12255372(T;T) | increased breast cancer, type-2 diabetes, and aggressive prostate cancer risk |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs12255372(G;G) | 00 | |
| Rs12255372(G;T) | 22 | 1.3x increased type-2 diabetes risk |
| Rs12255372(T;T) | 3.53.5 | increased breast cancer, type-2 diabetes, and aggressive prostate cancer risk |
[PMID 17109766] is the paper which links it to Breast cancer. It suggests the T allele as increasing risk.
[PMID 16936217] reports the association of rs12255372 and rs7903146 with Type-2 diabetes in a Finnish sample.
rs12255372 Common variants (rs12255372 and rs7903146) in TCF7L2 seem to be associated with an increased risk of diabetes among persons with impaired glucose tolerance
[PMID 17671651] Considered for type-2 diabetes with rs7903146 rs12255372 rs10885406.
[PMID 17971425] Associated in a study of ~1000 Hispanic-Americans with reduced insulin secretion as measured by acute insulin response and adjusted for the degree of insulin sensitivity (p = 0.036).
[PMID 18302196] In a study of 1,457 prostate cancer cases and 1,351 controls, while there was no association with overall risk, males who were rs12255372(T;T) homozygotes and who had prostate cancer were at elevated relative risk of more aggressive prostate cancer, as defined by high Gleason score (OR = 1.7, CI: 1.0-2.8) or regional/distant stage (OR = 1.7, CI: 1.1-2.6) disease.
[PMID 19033397] This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).
A HuGE review and meta-analysis including over 35,000 type-2 diabetes cases and 39,000 controls concluded that the Bayesian odds ratio for rs12255372(T;T) homozygotes and (G;T) heterozygotes versus (G;G) homozygotes was 1.885 (95% credible interval (CrI): 1.698 - 2.088) and 1.360 (95% CrI: 1.291 - 1.433), respectively. Along with 3 other TCF7L2 SNPs, a multiplicative genetic model was indicated.[PMID 19228405]
| ? | (G;G) (G;T) (T;T) |
|---|---|
|
| |
[PMID 18972257] Comparison of genetic risk in three candidate genes (TCF7L2, PPARG, KCNJ11) with traditional risk factors for type 2 diabetes in a population-based study--the HUNT study
[PMID 19183934] TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study
[PMID 19732438] No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer
| PharmGKB | PA161660934 |
| Name | |
| Annotation | The variant in the intronic region of TCF7L2 was found to substantially contribute to the risk of type 2 diabetes. The TCF7L2 variant influences therapeutic response to sulfonylureas but not metformin. |
| Gene | TCF7L2 |
| Featue | |
| Evidence | PubMed ID:17519421 |
| Drugs | |
| Diseases | Diabetes Mellitus, Type 2 |
| Curation Level | Curated |
[PMID 20028944] Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a risk population for type 2 diabetes
